EFFECTS OF AN ACUTE WATER LOAD ON PLASMA ANP AND AVP, AND RENAL WATER HANDLING IN HYPOTHYROIDISM - COMPARISON OF BEFORE AND AFTER L-THYROXINE TREATMENT

被引:13
作者
OTA, K
KIMURA, T
SAKURADA, T
SHOJI, M
INOUE, M
SATO, K
OHTA, M
YAMAMOTO, T
FUNYU, T
YOSHIDA, K
ABE, K
机构
[1] The Second Department of Internal Medicine, Tohoku University School of Medicine
[2] Yamagata Municipal Hospital Saiseikan, Yamagata
关键词
VASOPRESSIN; NATRIURETIC PEPTIDE; THYROID HORMONE; DIURESIS; URINARY DILUTION;
D O I
10.1507/endocrj.41.99
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To assess whether atrial natriuretic peptide (ANP) and arginine vasopressin (AVP) participate in impaired water excretion in patients with hypothyroid states (HS), an oral acute water loading (WL) test (20 ml/kg-BW/45 min) was performed before and after L-thyroxine (T4) treatment in 5 hypothyroid patients. Plasma ANP, AVP, osmolality (Posm), total protein and renal water excretion were simultaneously determined, and these data were compared to the data from five normal subjects (NS). The impaired water excretion rate in HS was entirely improved in the euthyroid states (ES) after T4 therapy for at least 7 months. Plasma ANP in HS was lower than that in NS (5.9+/-0.9 vs. 16.5+/-3.6 pmol/L, P<0.05), but increased after T4 treatment (21.2+/-5.7 pmol/L, P<0.05). Plasma AVP in HS (1.6+/-0.5 pmol/L) showed a tendency to be lower than those in ES and NS (2.9+/-0.4 and 2.9+/-0.7 pmol/L), but did not respond to a fall in Posm after WL, unlike ES and NS. Significant positive correlations were noticed between Posm and plasma AVP in ES and NS, but not in HS. These results suggest that not only the impaired release and/or metabolisms of AVP and ANP, but also derangement of renal water and electrolytes handling might induce attenuation Of C(H2O) formation in hypothyroid states.
引用
收藏
页码:99 / 105
页数:7
相关论文
共 21 条
[1]   SINGLE-COMPARTMENT MODEL ANALYSIS OF THYROTROPIN-RELEASING-HORMONE KINETICS IN HYPERTHYROID AND HYPOTHYROID PATIENTS - KINETIC-STUDIES USING A COMBINED SYSTEM OF RIA AND FPLC [J].
DUNTAS, L ;
KECK, FS ;
ROSENTHAL, J ;
WOLF, C ;
LOOS, U ;
PFEIFFER, EF .
KLINISCHE WOCHENSCHRIFT, 1990, 68 (20) :1013-1019
[2]   ALTERED THYROIDAL STATUS AND THE INVIVO SYNTHESIS OF ATRIAL-NATRIURETIC-PEPTIDE IN THE RAT-HEART [J].
FULLERTON, MJ ;
STUCHBURY, S ;
KROZOWSKI, ZS ;
FUNDER, JW .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1990, 69 (2-3) :227-233
[3]   GLOMERULAR DYNAMICS IN THE HYPOTHYROID RAT AND THE ROLE OF THE RENIN-ANGIOTENSIN SYSTEM [J].
GILLUM, DM ;
FALK, SA ;
HAMMOND, WS ;
CONGER, JD .
AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 253 (01) :F170-F179
[4]   DYNAMICS OF 24-HOUR ENDOGENOUS CORTISOL SECRETION AND CLEARANCE IN PRIMARY HYPOTHYROIDISM ASSESSED BEFORE AND AFTER PARTIAL THYROID-HORMONE REPLACEMENT [J].
IRANMANESH, A ;
LIZARRALDE, G ;
JOHNSON, ML ;
VELDHUIS, JD .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1990, 70 (01) :155-161
[5]   OSMOREGULATION OF PLASMA VASOPRESSIN IN MYXEDEMA - COMMENT [J].
IWASAKI, Y ;
OISO, Y ;
YAMAUCHI, K ;
TAKATSUKI, K ;
KONDO, K ;
HASEGAWA, H ;
TOMITA, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1990, 70 (02) :534-539
[6]   RADIOIMMUNOASSAY OF ARGININE VASOPRESSIN IN HUMAN-PLASMA AND URINE, A RESIN MICROCOLUMN METHOD [J].
KIMURA, T ;
MATSUI, K ;
OTA, K ;
YOSHINAGA, K .
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 1980, 131 (01) :37-46
[7]   EFFECTS OF ACUTE WATER LOAD, HYPERTONIC SALINE INFUSION, AND FUROSEMIDE ADMINISTRATION ON ATRIAL-NATRIURETIC-PEPTIDE AND VASOPRESSIN RELEASE IN HUMANS [J].
KIMURA, T ;
ABE, K ;
OTA, K ;
OMATA, K ;
SHOJI, M ;
KUDO, K ;
MATSUI, K ;
INOUE, M ;
YASUJIMA, M ;
YOSHINAGA, K .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1986, 62 (05) :1003-1010
[8]   THE ROLE OF CENTRAL ALPHA-1-ADRENOCEPTOR AND ALPHA-2-ADRENOCEPTOR IN THE REGULATION OF VASOPRESSIN RELEASE AND THE CARDIOVASCULAR-SYSTEM [J].
KIMURA, T ;
SHOJI, M ;
IITAKE, K ;
OTA, K ;
MATSUI, K ;
YOSHINAGA, K .
ENDOCRINOLOGY, 1984, 114 (04) :1426-1432
[9]  
KLEEMAN CR, 1986, THYROID FUNDAMENTAL, P1009
[10]   ATRIAL NATRIURETIC POLYPEPTIDE IN ATRIA AND PLASMA IN EXPERIMENTAL HYPERTHYROIDISM AND HYPOTHYROIDISM [J].
KOHNO, M ;
TAKAORI, K ;
MATSUURA, T ;
MURAKAWA, K ;
KANAYAMA, Y ;
TAKEDA, T .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 134 (01) :178-183