IMPORTANCE OF BONE-MARROW CYTOGENETIC EVALUATION BEFORE AUTOLOGOUS BONE-MARROW TRANSPLANTATION FOR HODGKINS-DISEASE

被引：63

作者：

CHAO, NJ

NADEMANEE, AP

LONG, GD

SCHMIDT, GM

DONLON, TA

PARKER, P

SLOVAK, ML

NAGASAWA, LS

BLUME, KG

FORMAN, SJ

机构：

[1] CITY HOPE NATL MED CTR,DIV PATHOL,DEPT HEMATOL & BONE MARROW TRANSPLANTAT,1500 E DUARTE RD,DUARTE,CA 91010

[2] STANFORD UNIV,MED CTR,DEPT MED,STANFORD,CA 94305

[3] STANFORD UNIV,MED CTR,DEPT PATHOL,STANFORD,CA 94305

[4] STANFORD UNIV,MED CTR,BONE MARROW TRANSPLANT PROGRAM,STANFORD,CA 94305

来源：

JOURNAL OF CLINICAL ONCOLOGY | 1991年 / 9卷 / 09期

关键词：

D O I：

10.1200/JCO.1991.9.9.1575

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Alkylating agents used either with or without radiation therapy have been associated with the development of myelodysplastic syndrome (MDS) and acute nonlymphoblastic leukemia (ANLL) after treatment of both malignant and nonmalignant disorders. This report describes seven patients with recurrent Hodgkin's disease (HO) evaluated for bone marrow transplantation (BMT) who developed chromosomal abnormalities, and emphasizes the importance of bone marrow cytogenetic studies before bone marrow harvest. Three patients with histologically normal bone marrow underwent autologous BMT and subsequently developed an MDS or ANLL. Four patients had the clonal abnormality detected before bone marrow harvest and did not proceed to BMT. © 1991 by American Society of Clinical Oncology.

引用

页码：1575 / 1579

页数：5

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