AN ANTIFUNGAL GAMMA-PYRONE AND XANTHONES WITH MONOAMINE-OXIDASE INHIBITORY ACTIVITY FROM HYPERICUM BRASILIENSE

被引：100

作者：

ROCHA, L

MARSTON, A

KAPLAN, MAC

STOECKLIEVANS, H

THULL, U

TESTA, B

HOSTETTMANN, K

机构：

[1] UNIV LAUSANNE, ECOLE PHARM, INST PHARMACOGNOSIE & PHYTOCHIM, CH-1015 LAUSANNE, SWITZERLAND

[2] UNIV LAUSANNE, ECOLE PHARM, INST CHIM THERAPEUT, CH-1015 LAUSANNE, SWITZERLAND

[3] UNIV FED RIO DE JANEIRO, NPNN, BR-21941 RIO DE JANEIRO, BRAZIL

[4] UNIV NEUCHATEL, INST CHIM, CH-2000 NEUCHATEL, SWITZERLAND

来源：

PHYTOCHEMISTRY | 1994年 / 36卷 / 06期

关键词：

HYPERICUM BRASILIENSE; GUTTIFERAE; STEMS; ROOTS; XANTHONES; GAMMA-PYRONE; HYPERBRASILONE; ANTIFUNGAL ACTIVITY; CLADOSPORIUM CUCUMERINUM; MAO INHIBITION; POLYPHENOLS;

D O I：

10.1016/S0031-9422(00)89727-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new gamma-pyrone (hyperbrasilone), three known xanthones (1,5-dihydroxyxanthone, 5-hydroxy-1-methoxyxanthone and 6-deoxyjacareubin) and betulinic acid have been isolated from a dichloromethane extract of stems and roots of Hypericum brasiliense. Their structures were established by spectroscopic methods (UV, EI-MS, H-1 and C-13 NMR) and that of the gamma-pyrone was confirmed by X-ray crystallography. Hyperbrasilone and the xanthones were all antifungal against Cladosporium cucumerinum, while the three xanthones showed differing degrees of inhibition of monoamine oxidase A and B.

引用

页码：1381 / 1385

页数：5

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