SIDE-EFFECTS OF ETIOTROPIC AGENTS IN PATIENTS WITH TUBERCULOSIS

Side-effects of antitubercular drugs were evaluated in 662 patients with tuberculosis. Simultaneously 406 of them suffered of chronic alcoholism, 94 suffered of heavy drinking and 162 were not alcohol abusers. The frequency of side-effects in patients with tuberculosis was 31.5 % and 56.4 % in those with concomitant alcoholism. The latter showed more frequently negative responses to streptomycin. The latter showed more frequently negative responses to streptomycin, ethionamide, rifampycin and kanamycin. They developed toxic reactions that were three times more frequent than in those without alcohol abuse and were acompanied by exacerbation of diseases of the liver, stomach, heart, CNS, peripheral nervous system.