ANOMALOUS GENE-EXPRESSION IN ALZHEIMER-DISEASE - CAUSE OR EFFECT

被引：4

作者：

MCLACHLAN, DRC ^{[1
]}

LUKIW, WJ ^{[1
]}

MIZZEN, C ^{[1
]}

PERCY, ME ^{[1
]}

SOMERVILLE, MJ ^{[1
]}

SUTHERLAND, MK ^{[1
]}

WONG, L ^{[1
]}

机构：

[1] SURREY PL CTR,DEPT GENET,TORONTO M5S 2C2,ONTARIO,CANADA

来源：

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1991年 / 18卷 / 03期

关键词：

D O I：

10.1017/S0317167100032571

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Altered chromatin conformation and increased amounts of aluminum have been observed in the brains of patients with Alzheimer disease. These factors have been shown to affect gene regulation. In this report, we describe how these changes may selectively alter the pool size of the human light chain neurofilament gene and play a fundamental role in the expression of this disease.

引用

页码：414 / 418

页数：5

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