Ho:YAG, Nd:YAG, and Erb:YAG laser ablation of Polymethyl-methacrylate (PMMA) was investigated under in vitro and simulated clinical conditions. Ablation rates were measured for all lasers and after ablation, macroscopic and microscopic appearance of the ablation site was investigated. The mean ablation rates of the Erb:YAG, Ho:YAG, and Nd:YAG laser increased from 8 mu m per pulse at 100 mJ to 44 mu m per pulse at 300 mJ from 100 mu m per pulse at 200 mJ to 222 mu m per pulse at 800 mJ and from 28 mu m per pulse at 100 mJ to 189 mu m per pulse at 800 mJ, respectively. Macroscopic investigation exhibited melting of bone cement for the Ho:YAG and Nd:YAG lasers and pulse-to-pulse vaporization for the Erb:YAG laser. The width of thermal alteration, however, was comparable for all lasers used. Removal of cement from bone specimens under simulated clinical conditions showed good detachment of cement when the fiber was used parallel; in case of perpendicular use, remainders of cement and carbonization of bone could be observed upon histological investigation. (C) 1993 Wiley-Liss, Inc.