OPPOSITE ACTION OF OXYTOCIN AND ITS PEPTIDE ANTAGONISTS ON SOCIAL MEMORY IN RATS

被引：64

作者：

POPIK, P

VETULANI, J

机构：

[1] Polish Academy of Sciences, Institute of Pharmacology, 31-343 Kraków

来源：

NEUROPEPTIDES | 1991年 / 18卷 / 01期

关键词：

D O I：

10.1016/0143-4179(91)90159-G

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The synthetic 1-beta, beta-disubstituted analogues of [1-deamino]-oxytocin, [1'-(1'-thio-4'-methylcyclohexane)-acetic acid 1]-oxytocin (MeCAOT) a peripheral oxytocin antagonist, and [1'-(1'-methyl-4'-thiopiperidine)-acetic acid 1]-oxytocin (MePAOT), devoid of peripheral antioxytocin activity, were found to improve social memory of rats. The social memory in rats was disrupted by a wide range of doses of oxytocin (6-750 mU/kg) and this amnestic effect of oxytocin was antagonised by MePAOT and MeCAOT.

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页码：23 / 27

页数：5

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