LACTENDIYNES - A NEW CLASS OF TRIGGERED CYCLIC ENEDIYNES

被引：60

作者：

BANFI, L ^{[1
]}

GUANTI, G ^{[1
]}

机构：

[1] CNR,IST CHIM ORGAN,CTR STUDIO CHIM COMPOSTI CICLOALIFATICI & AROMAT,I-16132 GENOA,ITALY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 21期

关键词：

ANTITUMOR AGENTS; AZETIDINONES; CYCLOAROMATIZATIONS; ENEDIYNES;

D O I：

10.1002/anie.199523931

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A promising prodrug, the stable cyclic enediyne 1, unleashes a reactive, potentially DNA‐damaging enediyne when the β‐lactam group is hydrolyzed under basic conditions. This intermediate rapidly undergoes cycloaromatization giving a phenylene diradical, which can be trapped by 1,4‐cyclohexadiene. R1, R2  OMe, H. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：2393 / 2395

页数：3

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