PROGESTERONE INDUCES HUMAN SPERM CHEMOTAXIS

被引：64
作者：
VILLANUEVADIAZ, C
ARIASMARTINEZ, J
BERMEJOMARTINEZ, L
VADILLOORTEGA, F
机构：
[1] INST NACL PERINATOL,DEPT BIOQUIM,MEXICO CITY 11000,DF,MEXICO
[2] INST NACL PERINATOL,DEPT FISIOL REPROD,MEXICO CITY 11000,DF,MEXICO
来源：
FERTILITY AND STERILITY | 1995年 / 64卷 / 06期
关键词：
SPERM CHEMOTAXIS; PROGESTERONE; HUMAN SPERM; FOLLICULAR FLUID;
D O I：
10.1016/S0015-0282(16)57982-5
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To characterize the molecular nature of the chemotactic signal for sperm contained in human follicular fluid (FF). Design: Follicular fluid was fractionated and several procedures were followed to the physicochemical initial characterization of sperm chemotactic compound(s). Main Outcome Measure: Relative chemotactic activity of each fraction was measured in a double chamber device. Results: Sperm chemotaxis was found to be associated with a lipid-like molecule extracted from FF. Several steroids were assayed individually and only P showed sperm chemotactic properties in dose-response curves. Conclusions: In this paper we present experimental evidence to support the hypothesis that P, the main steroid component of FF, is a mediator of sperm chemoattraction in human beings.
引用
收藏
页码：1183 / 1188
页数：6
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