COMPARISON OF BALANOL FROM VERTICILLIUM BALANOIDES AND OPHIOCORDIN FROM CORDYCEPS OPHIOGLOSSOIDES

被引：30
作者：
BOROS, C
HAMILTON, SM
KATZ, B
KULANTHAIVEL, P
机构：
[1] SPHINX PHARMACEUT CORP,DEPT CHEM RES,NAT PROD DISCOVERY,DURHAM,NC 27717
[2] MYCOSEARCH INC,DURHAM,NC 27707
来源：
JOURNAL OF ANTIBIOTICS | 1994年 / 47卷 / 09期
关键词：
D O I：
10.7164/antibiotics.47.1010
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Recently, we reported the isolation of the potent protein kinase C inhibitor balanol (1) from the fungus Verticillium balanoides. In an earlier study, KONIG et al, reported the isolation of ophiocordin (3), a structural isomer of 1, from the fungus Cordyceps ophioglossoides. The present study was designed to clarify whether or not balanol and ophiocordin are different compounds. The results indicated that the two fungi produced the same compound, the structure being that assigned to balanol. In addition, a thirty-fold increase in the production of balanol from V. balanoides was observed when the culture medium was changed from cornmeal/tomato paste to soy meal/glycerol.
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页码：1010 / 1016
页数：7
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