SYNTHESIS AND MICROBIOLOGICAL ACTIVITY OF 5-METHYL-2-[PARA-SUBSTITUTED PHENYL]BENZOXAZOLES

被引：82

作者：

YALCIN, I ^{[1
]}

SENER, E ^{[1
]}

OZDEN, T ^{[1
]}

OZDEN, S ^{[1
]}

AKIN, A ^{[1
]}

机构：

[1] ANKARA UNIV,FAC PHARM,DEPT MICROBIOL,ANKARA 06100,TURKEY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 25卷 / 08期

关键词：

2,5-disubstituted benzoxazoles; anti-microbiological activity;

D O I：

10.1016/0223-5234(90)90137-R

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and microbiological activity of a series of 5-methyl-2-(p-substituted phenyl)benzoxazoles 7a-7g are described. The in vitro microbiological activity of these compounds was determined against some Gram-positive and Gram-negative bacteria and C albicans. The observed minimum inhibitory concentration (MIC) values of the derivatives were compared to some other 2,5-disubstituted benzoxazoles and clinically used drugs. The in vitro microbiological data showed that the derivatives 7a-7g exhibited a broad spectrum of antibacterial activity and 7a-c and 7g were significantly active against E coli and/or K pneumoniae at an MIC of 6.2 μg/ml. © 1990.

引用

页码：705 / 708

页数：4

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