Ion mobility spectrometry of talarozole, a new azole drug, in cleaning quality control

被引：5
作者：
Baert, Bram [1 ]
Boonen, Jente [1 ]
Thierens, Celine [1 ]
De Spiegeleer, Bart [1 ]
机构：
[1] Univ Ghent, Fac Pharmaceut Sci, Dept Pharmaceut Anal, Drug Qual & Registrat DruQuaR Grp, Harelbekestraat 72, B-9000 Ghent, Belgium
来源：
INTERNATIONAL JOURNAL FOR ION MOBILITY SPECTROMETRY | 2011年 / 14卷 / 2-3期
关键词：
Ion Mobility Spectrometry (IMS); Azole drug; Talarozole (rambazole); Experimental design; Cleaning;
D O I：
10.1007/s12127-011-0063-z
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
Ion mobility spectrometry (IMS) gains increased pharmaceutical interest as an analytical technique for the verification of equipment cleaning. Using a fractional factorial design, we developed an IMS method for talarozole, which represents a new generation of retinoic acid metabolism blocking agents (RAMBA) that can be used for the treatment of different dermatological diseases, such as psoriasis and acne. Using a Smiths Detection Ionscan-LS and the optimal IMS settings obtained, talarozole showed a drift time of 16.648 ms, corresponding to a reduced ion mobility K-0 of 1.072 cm(2)V(-1)s(-1). Total analysis times below 1 min were achieved. Talarozole was well separated in the plasmagram from other azole compounds and the limit of detection was found to be 43 ng/ml. Swab samples collected from steel and glass plates were successfully analyzed, thereby showing that IMS is indeed a suitable technique for the quantitative analysis of talarozole in cleaning quality control.
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收藏
页码：109 / 116
页数：8
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