CLONING OF THE BETA-SUBUNIT OF THE LEUKOCYTE ADHESION PROTEINS - HOMOLOGY TO AN EXTRACELLULAR-MATRIX RECEPTOR DEFINES A NOVEL SUPERGENE FAMILY

被引：513

作者：

KISHIMOTO, TK ^{[1
]}

OCONNOR, K ^{[1
]}

LEE, A ^{[1
]}

ROBERTS, TM ^{[1
]}

SPRINGER, TA ^{[1
]}

机构：

[1] HARVARD UNIV, SCH MED, DANA FARBER CANC INST, DIV NEOPLAST DIS MECHANISMS, BOSTON, MA 02115 USA

来源：

CELL | 1987年 / 48卷 / 04期

关键词：

D O I：

10.1016/0092-8674(87)90246-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have isolated cDNA clones encoding the .beta. subunit of the human LFA-1, Mac-1, and p150,95 family of leukocyte adhesion proteins. The deduced 769-amino-acid sequence defines a cysteine-rich polypeptide with the characteristic features of an integral membrane protein. Peptide sequence data, Northern blot analysis, and Southern blot analysis suggest that a single gene encodes the .beta. subunit of all three leukocyte adhesion proteins. There is 45% homology between the .beta. subunit sequence and band III of integrin, a chick fibronectin and laminin receptor. This homology defines a new supergene family of cellular adhesion proteins.

引用

页码：681 / 690

页数：10

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