CLONING OF THE BETA-SUBUNIT OF THE LEUKOCYTE ADHESION PROTEINS - HOMOLOGY TO AN EXTRACELLULAR-MATRIX RECEPTOR DEFINES A NOVEL SUPERGENE FAMILY

被引：513
作者：
KISHIMOTO, TK [1 ]
OCONNOR, K [1 ]
LEE, A [1 ]
ROBERTS, TM [1 ]
SPRINGER, TA [1 ]
机构：
[1] HARVARD UNIV, SCH MED, DANA FARBER CANC INST, DIV NEOPLAST DIS MECHANISMS, BOSTON, MA 02115 USA
来源：
CELL | 1987年 / 48卷 / 04期
关键词：
D O I：
10.1016/0092-8674(87)90246-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have isolated cDNA clones encoding the .beta. subunit of the human LFA-1, Mac-1, and p150,95 family of leukocyte adhesion proteins. The deduced 769-amino-acid sequence defines a cysteine-rich polypeptide with the characteristic features of an integral membrane protein. Peptide sequence data, Northern blot analysis, and Southern blot analysis suggest that a single gene encodes the .beta. subunit of all three leukocyte adhesion proteins. There is 45% homology between the .beta. subunit sequence and band III of integrin, a chick fibronectin and laminin receptor. This homology defines a new supergene family of cellular adhesion proteins.
引用
收藏
页码：681 / 690
页数：10
相关论文
共 51 条
  • [1] ANDERSON DC, 1986, J IMMUNOL, V137, P15
  • [2] ANDERSON DC, 1987, IN PRESS ANN REV MED
  • [3] ANTI-MAC-1 SELECTIVELY INHIBITS THE MOUSE AND HUMAN TYPE 3 COMPLEMENT RECEPTOR
    BELLER, DI
    SPRINGER, TA
    SCHREIBER, RD
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1982, 156 (04) : 1000 - 1009
  • [4] CARPEN O, 1986, 6TH INT C IMM TOR, V315, P572
  • [5] PLATELET GLYCOPROTEIN-IIB AND GLYCOPROTEIN-IIIA - EVIDENCE FOR A FAMILY OF IMMUNOLOGICALLY AND STRUCTURALLY RELATED GLYCOPROTEINS IN MAMMALIAN-CELLS
    CHARO, IF
    FITZGERALD, LA
    STEINER, B
    RALL, SC
    BEKEART, LS
    PHILLIPS, DR
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (21) : 8351 - 8355
  • [6] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE
    CHIRGWIN, JM
    PRZYBYLA, AE
    MACDONALD, RJ
    RUTTER, WJ
    [J]. BIOCHEMISTRY, 1979, 18 (24) : 5294 - 5299
  • [7] REDUCED SURFACE EXPRESSION AND BINDING OF FIBRONECTIN BY THROMBIN-STIMULATED THROMBASTHENIC PLATELETS
    GINSBERG, MH
    FORSYTH, J
    LIGHTSEY, A
    CHEDIAK, J
    PLOW, EF
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1983, 71 (03) : 619 - 624
  • [8] HARA T, 1986, LEUKOCYTE TYPING 2, V3, P77
  • [9] CHARACTERIZATION OF A MEMBRANE-ASSOCIATED GLYCOPROTEIN COMPLEX IMPLICATED IN CELL-ADHESION TO FIBRONECTIN
    HASEGAWA, T
    HASEGAWA, E
    CHEN, WT
    YAMADA, KM
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 1985, 28 (04) : 307 - 318
  • [10] Heggeness M H, 1978, Ann N Y Acad Sci, V312, P414, DOI 10.1111/j.1749-6632.1978.tb16822.x
123456