ESTABLISHMENT AND VALIDATION OF A DOSE-EFFECT CURVE FOR GAMMA-RAYS BY CYTOGENETIC ANALYSIS

被引：32

作者：

BARQUINERO, JF

BARRIOS, L

CABALLIN, MR

MIRO, R

RIBAS, M

SUBIAS, A

EGOZCUE, J

机构：

[1] UNIV AUTONOMA BARCELONA,FAC CIENCIAS,DEPT CELLULAR & FISIOL,UNITAT BIOL CELLULAR,E-08193 BARCELONA,SPAIN

[2] UNIV AUTONOMA BARCELONA,INST BIOL FONDAMENTAL VICENT VILLAR PALASI,E-08193 BARCELONA,SPAIN

[3] UNIV AUTONOMA BARCELONA,FAC MED,DEPT BIOL CELLULAR & FISIOL,UNITAT BIOL,E-08193 BARCELONA,SPAIN

[4] UNIV AUTONOMA BARCELONA,HOSP SANTA CREU & ST PAU,ONCOL SERV,E-08193 BARCELONA,SPAIN

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1995年 / 326卷 / 01期

关键词：

DOSE-EFFECT CURVE; GAMMA-RAYS; CYTOGENETIC ANALYSIS;

D O I：

10.1016/0027-5107(94)00150-4

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A dose-effect curve obtained by analysis of dicentric chromosomes after irradiation of peripheral blood samples, from one donor, at 11 different doses of gamma-rays is presented. For the elaboration of this curve, more than 18 000 first division metaphases have been analyzed. The results fit very well to the linear-quadratic model. To validate the curve, samples from six individuals (three controls and three occupationally exposed persons) were irradiated at 2 Gy. The results obtained, when compared with the curve, showed that in all cases the 95% confidence interval included the 2 Gy dose, with estimated dose ranges from 1.82 to 2.19 Gy.

引用

页码：65 / 69

页数：5

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