TUMOR-SUPPRESSOR GENE-PRODUCTS IN CELL CONTACTS - THE CADHERIN-APC-ARMADILLO CONNECTION

被引：110
作者：
HULSKEN, J
BEHRENS, J
BIRCHMEIER, W
机构：
[1] Max-Delbruck-Center for Molecular Medicine, Berlin
来源：
CURRENT OPINION IN CELL BIOLOGY | 1994年 / 6卷 / 05期
关键词：
D O I：
10.1016/0955-0674(94)90098-1
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Various structural components of intercellular junctions have recently been found to represent (or be related to) products of tumor-suppressor genes. The tumor-suppressor gene product adenomatous polyposis coil (APC) binds to beta(2)-catenin (homologous to the product of Drosophila armadillo), which is cytoplasmically associated with the cell adhesion molecule E-cadherin.
引用
收藏
页码：711 / 716
页数：6
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