CELL BIOLOGY OF THE AMYLOID BETA-PROTEIN PRECURSOR AND THE MECHANISM OF ALZHEIMERS-DISEASE

被引：39
作者：
SELKOE, DJ
机构：
[1] HARVARD UNIV,SCH MED,PROGRAM NEUROSCI,BOSTON,MA 02115
[2] BRIGHAM & WOMENS HOSP,CTR NEUROL DIS,BOSTON,MA 02115
来源：
ANNUAL REVIEW OF CELL BIOLOGY | 1994年 / 10卷
关键词：
MEMBRANE PROTEINS; ENDOCYTOSIS; PROTEOLYSIS; POLARIZED CELLS; NEURODEGENERATION;
D O I：
10.1146/annurev.cb.10.110194.002105
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页码：373 / 403
页数：31
相关论文
共 50 条
[21]   SELECTIVE ECTODOMAIN PHOSPHORYLATION AND REGULATED CLEAVAGE OF BETA-AMYLOID PRECURSOR PROTEIN [J].
HUNG, AY ;
SELKOE, DJ .
EMBO JOURNAL, 1994, 13 (03) :534-542
[22]   EVIDENCE FOR THE ASSOCIATION OF PROTEIN-4.1 IMMUNOREACTIVE FORMS WITH NEUROFIBRILLARY TANGLES IN ALZHEIMERS-DISEASE BRAINS [J].
SIHAG, RK ;
WANG, LW ;
CATALDO, AM ;
HAMLIN, M ;
COHEN, CM ;
NIXON, RA .
BRAIN RESEARCH, 1994, 656 (01) :14-26
[23]   A SERINE-PROTEASE IN ALZHEIMERS-DISEASE CELLS CLEAVES A 16K-PEPTIDE WITH FLANKING RESIDUES UPSTREAM TO BETA-AMYLOID-N-TERMINUS AS NATURAL SUBSTRATE [J].
MATSUMOTO, A ;
MATSUMOTO, R ;
BABA, H ;
FUJIWARA, Y .
NEUROSCIENCE LETTERS, 1995, 195 (03) :171-174
[24]   SELECTIVE NEUROTOXICITY OF COOH-TERMINAL FRAGMENTS OF THE BETA-AMYLOID PRECURSOR PROTEIN [J].
FUKUCHI, K ;
SOPHER, B ;
FURLONG, CE ;
SMITH, AC ;
DANG, NT ;
MARTIN, GM .
NEUROSCIENCE LETTERS, 1993, 154 (1-2) :145-148
[25]   GLIAL EXPRESSION OF THE BETA-AMYLOID PRECURSOR PROTEIN (APP) IN GLOBAL-ISCHEMIA [J].
BANATI, RB ;
GEHRMANN, J ;
WIESSNER, C ;
HOSSMANN, KA ;
KREUTZBERG, GW .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1995, 15 (04) :647-654
[26]   Trafficking of cell-surface beta-amyloid precursor protein: Evidence that a sorting intermediate participates in synaptic vesicle recycling [J].
MarquezSterling, NR ;
Lo, ACY ;
Sisodia, SS ;
Koo, EH .
JOURNAL OF NEUROSCIENCE, 1997, 17 (01) :140-151
[27]   Quantitative neuropathological assessment of Alzheimer disease and amyloid precursor protein transgenic mice [J].
Irizarry, MC ;
Gomez-Isla, T ;
Gomez-Tortosa, E ;
Hyman, BT .
FRONTIERS OF THE MECHANISMS OF MEMORY AND DEMENTIA, 2000, (1200) :133-136
[28]   Zinc and copper effect mechanical cell adhesion properties of the amyloid precursor protein [J].
August, Alexander ;
Hartmann, Sabrina ;
Schilling, Sandra ;
Mueller-Renno, Christine ;
Begic, Tarik ;
Pierik, Antonio J. ;
Ziegler, Christiane ;
Kins, Stefan .
BIOLOGICAL CHEMISTRY, 2024, 405 (11-12) :701-710
[29]   Overexpressions of cDNAs for beta-amyloid precursor proteins 695, 751, and 770 enhance the secretion of beta-amyloid precursor protein derivatives and the survival of P19-derived neurons [J].
Fukuchi, K ;
Ohman, T ;
Dang, N ;
Smith, AC ;
Furlong, CE ;
Martin, GM .
JOURNAL OF NEUROCHEMISTRY, 1996, 66 (05) :2201-2204
[30]   CHLOROQUINE INHIBITS INTRACELLULAR DEGRADATION BUT NOT SECRETION OF ALZHEIMER BETA/A4 AMYLOID PRECURSOR PROTEIN [J].
CAPORASO, GL ;
GANDY, SE ;
BUXBAUM, JD ;
GREENGARD, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (06) :2252-2256
12345