ANGIOTENSIN-IV REVERSES THE ACUTE CEREBRAL BLOOD-FLOW REDUCTION AFTER EXPERIMENTAL SUBARACHNOID HEMORRHAGE IN THE RAT

被引：0

作者：

NAVERI, L ^{[1
]}

STROMBERG, C ^{[1
]}

SAAVEDRA, JM ^{[1
]}

机构：

[1] NIMH,CLIN SCI LAB,PHARMACOL SECT,BETHESDA,MD 20892

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 1994年 / 14卷 / 06期

关键词：

ANGIOTENSIN IV; CEREBRAL BLOOD FLOW; SUBARACHNOID HEMORRHAGE; NITRIC OXIDE SYNTHASE; CEREBRAL ARTERIES;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of angiotensin (ANG) IV on CBF after experimental subarachnoid hemorrhage (SAH) was studied in rats using laser-Doppler flowmetry. ANG IV (1 mu g/kg/min i.v.) or saline treatments were started 20 min after SAH. ANG IV increased CBF (from 45 to 84% of baseline) by 60 min. In the saline group, CBF remained low (51%). Pretreatment with the specific ANG II antagonist Sar(1), Ile(8)-ANG II did not antagonize ANG IV. Determination of nitric oxide synthase (NOS) activity in vitro or inhibition of NOS in vivo did not support a role for NO in the action of ANG IV.

引用

页码：1096 / 1099

页数：4

共 22 条

[1]

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[2]

BENNETT JP, 1976, J BIOL CHEM, V251, P7423

[3] NITRIC-OXIDE MEDIATES GLUTAMATE-LINKED ENHANCEMENT OF CGMP LEVELS IN THE CEREBELLUM [J].