MARKED DECREASE OF A10-DOPAMINE NEURONAL FIRING DURING ETHANOL WITHDRAWAL SYNDROME IN RATS

被引：42

作者：

DIANA, M

PISTIS, M

MUNTONI, A

ROSSETTI, ZL

GESSA, G

机构：

[1] 'B.B. Brodie' Department of Neuroscience, University of Cagliari, 09124 Cagliari

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 221卷 / 2-3期

关键词：

DOPAMINE NEURONS; ETHANOL; WITHDRAWAL SYNDROME;

D O I：

10.1016/0014-2999(92)90734-L

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The electrophysiological activity of mesoaccumbens dopaminergic neurons was monitored during the ethanol-withdrawal syndrome in ethanol-dependent and in control rats. Spontaneous firing was reduced by about half in ethanol-dependent rats as compared to controls. Likewise, the number of spikes/burst was also reduced in ethanol-dependent rats. These results are consistent with the reduction in dopamine release observed during ethanol-withdrawal syndrome and may provide the basis for the aversive effects of the ethanol-withdrawal syndrome.

引用

页码：403 / 404

页数：2

共 5 条

[1]

DICHIARA G, 1988, P NATL ACAD SCI USA, V85, P5274

[2] LOW-DOSES OF ETHANOL ACTIVATE DOPAMINERGIC-NEURONS IN THE VENTRAL TEGMENTAL AREA [J].