THE SIGMA RECEPTOR LIGAND SR-31742A INCREASES NEUROTENSIN IN THE NUCLEUS-ACCUMBENS BUT NOT IN THE CAUDATE-PUTAMEN OF THE RAT

被引：3
作者：
LABIE, C
KEANE, PE
SOUBRIE, P
LEFUR, G
机构：
[1] SANOFI RECH,195 ROUTE ESPAGNE,F-31036 TOULOUSE,FRANCE
[2] SANOFI RECH,F-34184 MONTPELLIER,FRANCE
[3] SANOFI RECH,F-75008 PARIS,FRANCE
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 231卷 / 03期
关键词：
SR-31742A; NEUROTENSIN; DELTA RECEPTOR LIGANDS; ANTIPSYCHOTICS;
D O I：
10.1016/0014-2999(93)90125-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of SR 31742A, a specific sigma site ligand, were investigated on regional neurotensin concentrations in rat brain. Both acute and chronic (21-day) treatment with either SR 31742A (20 mg/kg i.p.) or haloperidol (1 mg/kg i.p.) increased the neurotensin-like immunoreactivity in the nucleus accumbens. In contrast to haloperidol, the administration of SR 31742A failed to increase the concentration of neurotensin-like immunoreactivity in the caudate-putamen. Thus, the effects of SR 31742A appear to be selective for the limbic system.
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收藏
页码：465 / 467
页数：3
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