A FLEXIBLE BIOSENSOR FOR GLUCOSE

被引:19
作者
MITSUBAYASHI, K
DICKS, JM
YOKOYAMA, K
TAKEUCHI, T
TAMIYA, E
KARUBE, I
机构
[1] Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, 153, 4‐6‐1 Komaba, Meguro‐ku
[2] Research Laboratories, Nippondenso Co, Ltd, Nisshin, Aichi, 470-01, 500‐1 Minamiyama, Komenoki‐cho
[3] Japan Advanced Institute for Science and Technology, (Jaist), Nomi-Gun, Ishikawa, 923-12, Hokuriku, 15 Asahidai, Tatsuguchi‐cho
关键词
FLEXIBLE BIOSENSOR; GOLD-COATED MEMBRANE; GLUCOSE; NONTOXICITY;
D O I
10.1002/elan.1140070110
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A flexible glucose biosensor was constructed by immobilizing glucose oxidase within a gold-coated, hydrophilic polytetrafluoroethylene membrane. All reagents and materials used were harmless and nontoxic. Enzyme immobilization was improved using a mesh mask during gold deposition, the grid pattern permitting better access into the membrane. The masked sensors had greatly improved output currents and linearity. The sensor was linear up to 662 mg L(-1), the range covering the concentrations encountered in normal and diabetic human tear fluids. The current was proportional to the square of the electrode area, hence an electrode of known dimensions can be used without precalibration. Sterilization using 80% ethanol had a negligible effect on its response. The sensor is well suited to the detection of glucose or other analytes in body fluids, such as tears, airway mucus, sweat, and saliva.
引用
收藏
页码:83 / 87
页数:5
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