NOREPINEPHRINE AND SEROTONIN INCREASE THE VASOCONSTRICTOR RESPONSE OF THE PERFUSED RAT TAIL ARTERY TO CHANGES IN CYTOSOLIC CA-2+

被引：13

作者：

THORINTRESCASES, N ^{[1
]}

OSTER, L ^{[1
]}

ATKINSON, J ^{[1
]}

CAPDEVILLE, C ^{[1
]}

机构：

[1] FAC SCI PHARMACEUT & BIOL PARIS,PHARMACOL LAB,F-54000 NANCY,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 179卷 / 03期

关键词：

(Rat); 5-HT; (5-hydroxytryptamine; serotonin); Ca[!sup]2+[!/sup; Fura 2-Ca[!sup]2+[!/sup] signal; Norepinephrine; Smooth muscle (vascular); Tail artery;

D O I：

10.1016/0014-2999(90)90191-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Vasoconstriction and changes in cytosolic free Ca2+ concentrations (fura 2 with dual wavelength excitation) were measured simultaneously in the perfused tail artery of the rat. Vasoconstrictors (norepinephrine and 5-HT) appear to modulate contraction not only by changing the cytosolic free Ca2+ concentration but also modifying the sensitivity of the contractile proteins to Ca2+. © 1990.

引用

页码：469 / 471

页数：3