NOREPINEPHRINE AND SEROTONIN INCREASE THE VASOCONSTRICTOR RESPONSE OF THE PERFUSED RAT TAIL ARTERY TO CHANGES IN CYTOSOLIC CA-2+

被引：13
|
作者：
THORINTRESCASES, N [1 ]
OSTER, L [1 ]
ATKINSON, J [1 ]
CAPDEVILLE, C [1 ]
机构：
[1] FAC SCI PHARMACEUT & BIOL PARIS,PHARMACOL LAB,F-54000 NANCY,FRANCE
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 179卷 / 03期
关键词：
(Rat); 5-HT; (5-hydroxytryptamine; serotonin); Ca[!sup]2+[!/sup; Fura 2-Ca[!sup]2+[!/sup] signal; Norepinephrine; Smooth muscle (vascular); Tail artery;
D O I：
10.1016/0014-2999(90)90191-8
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Vasoconstriction and changes in cytosolic free Ca2+ concentrations (fura 2 with dual wavelength excitation) were measured simultaneously in the perfused tail artery of the rat. Vasoconstrictors (norepinephrine and 5-HT) appear to modulate contraction not only by changing the cytosolic free Ca2+ concentration but also modifying the sensitivity of the contractile proteins to Ca2+. © 1990.
引用
收藏
页码：469 / 471
页数：3
相关论文
共 50 条
12345