CREATIVE BLOCKS - CELL-CYCLE CHECKPOINTS AND FEEDBACK CONTROLS

被引：658

作者：

MURRAY, AW

机构：

[1] Department of Physiology, University of California at San Francisco, Box 0444, San Francisco

来源：

NATURE | 1992年 / 359卷 / 6396期

关键词：

D O I：

10.1038/359599a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Before division, cells must ensure that they finish DNA replication, DNA repair and chromosome segregation. They do so by using feedback controls which can detect the failure to complete replication, repair or spindle assembly to arrest the progress of the cell cycle at one of three checkpoints. Failures in feedback controls can contribute to the generation of cancer.

引用

页码：599 / 604

页数：6

共 84 条

[1] A YEAST MUTANT, PRP20, ALTERED IN MESSENGER-RNA METABOLISM AND MAINTENANCE OF THE NUCLEAR-STRUCTURE, IS DEFECTIVE IN A GENE HOMOLOGOUS TO THE HUMAN GENE RCC1 WHICH IS INVOLVED IN THE CONTROL OF CHROMOSOME CONDENSATION [J].