CHEMICAL SYNTHESIS OF GAMMA-ECHISTATIN ANALOGS - ELUCIDATION OF STATUS OF C-TERMINAL-(45-49)

被引：7

作者：

CHEN, PY

WU, SH

WANG, KT

机构：

[1] ACAD SINICA,INST BIOL CHEM,TAIPEI,TAIWAN

[2] NATL TAIWAN UNIV,INST BIOCHEM SCI,TAIPEI,TAIWAN

来源：

PROTEIN ENGINEERING | 1994年 / 7卷 / 07期

关键词：

DISINTEGRIN; ECHISTATIN; PLATELET AGGREGATION; SOLID-PHASE PEPTIDE SYNTHESIS;

D O I：

10.1093/protein/7.7.941

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three analogues of gamma-echistatin, des(45-49)-gamma-echistatin, des(46-49)-gamma-echistatin and des(47-49)-gamma-echistatin, were synthesized by solid-phase methodology and their biological activities were measured and compared. The results reveal that without the C-terminal (45-49) of gamma-echistatin, the folding of the protein to the final active structure is not interfered with and Lys-45 influences the inhibition of platelet aggregation.

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页码：941 / 944

页数：4

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