Long-term pulmonary complications in sulfur mustard victims of Sardasht, Iran

被引：23

作者：

Pourfarzam, Shahryar ^{[2
]}

Ghazanfari, Tooba ^{[1
,3
]}

Merasizadeh, Javad ^{[4
]}

Ghanei, Mostafa ^{[4
]}

Azimi, Ghasem ^{[2
]}

Araghizadeh, Hassan

Foroutan, Abbas ^{[5
]}

Shams, Jalaleddin ^{[6
]}

Ghasemi, Hassan ^{[7
]}

Yaraee, Roya ^{[3
]}

Shariat-Panahi, Shamsa ^{[8
]}

Soroush, Mohammad Reza ^{[9
]}

Hassan, Zuhair Mohammad ^{[10
]}

Moaiedmohseni, Sakine ^{[13
]}

Nadoushan, Mohammad Reza Jalali ^{[14
]}

Fallahi, Faramarz ^{[11
]}

Mahdavi, Mohammad Reza Vaez ^{[12
]}

Moin, Athar ^{[15
]}

Ghazanfari, Zeinab ^{[16
]}

Ghaderi, Sulayman ^{[17
]}

Yarmohammadi, Mohammad Ebrahim ^{[2
]}

Naghizadeh, Mohammad Mehdi ^{[3
]}

Faghihzadeh, Soghrat ^{[18
]}

机构：

[1] Shahed Univ, Fac Med, Dept Immunol, Tehran, Iran

[2] Shahed Univ, Dept Internal Med, Tehran, Iran

[3] Shahed Univ, Immunoregulat Res Ctr, Tehran, Iran

[4] Baqiyatallah Univ Med Sci, Res Ctr Chem Injuries, Tehran, Iran

[5] Shahid Beheshti Univ Med Sci, Dept Physiol, Tehran, Iran

[6] Shahed Univ, Dept Hematol & Oncol, Tehran, Iran

[7] Shahed Univ, Dept Ophthalmol, Tehran, Iran

[8] Shahed Univ, Dept Rheumatol, Tehran, Iran

[9] JMERC, Tehran, Iran

[10] Tarbiat Modares Univ, Dept Immunol, Tehran, Iran

[11] Shahed Univ, Dept Cardiol, Tehran, Iran

[12] Shahed Univ, Dept Physiol, Tehran, Iran

[13] Shahed Univ, Med Res Ctr, Tehran, Iran

[14] Shahed Univ, Dept Pathol, Tehran, Iran

[15] Shahed Univ, Dept Dermatol, Tehran, Iran

[16] Ilam Univ Med Sci, Dept Hlth, Ilam, Iran

[17] Chem Victims Clin Sardasht, Sardasht, West Azarbaijan, Iran

[18] Tarbiat Modares Univ, Dept Biostat, Tehran, Iran

来源：

TOXIN REVIEWS | 2009年 / 28卷 / 01期

关键词：

Sulfur mustard; respiratory complications; FEV1; pulmonary function test; Sardasht-Iran Cohort Study; EXPOSURE; LUNG;

D O I：

10.1080/15569540802689220

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Sulfur mustard (SM) has widely been used against the military and civilians during the Iraq-Iran war (1980-1988). It mostly affects the respiratory system. A large historical cohort study was designed to evaluate the pulmonary status of non-military victims in Sardasht, Iran, in comparison with a matched control group 20 years after a single massive exposure. The exposed group was divided into two subgroups of hospitalized and non-hospitalized based on the severity of the injuries indicated by hospitalization a few days following exposure. All participants' respiratory symptoms and signs were evaluated by internists. Dyspnea (n = 261; P = 93.2%) was the most common symptom. Chronic cough, cough severity, sputum, hemoptysis, dyspnea, pattern of dyspnea, severity of dyspnea (P < 0.001 for all), and chest pain (P = 0.003) were statistically significantly different between the two groups. Wheezing was the most common pulmonary finding (11.4%). There was also a statistically significant difference in the auscultation of wheezing (P = 0.045) and rhonchi (P = 0.018) between the hospitalized and control groups. Considering objective findings, pulmonary involvement was observed in 24.3% (n = 68, P = 0.007).

引用

页码：8 / 13

页数：6

共 14 条

[1] STANDARDIZATION OF SPIROMETRY - 1994 UPDATE [J].