REGIONAL OXYGEN-CONSUMPTION PERSISTS IN DYSKINETIC CANINE MYOCARDIUM

被引：8

作者：

BUFFINGTON, CW ^{[1
]}

STRUM, DP ^{[1
]}

WATANABE, S ^{[1
]}

机构：

[1] UNIV PITTSBURGH,DEPT ANESTHESIOL & CRIT CARE MED,PITTSBURGH,PA 15213

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1994年 / 24卷 / 01期

关键词：

HEART; REGIONAL CONTRACTION; DYSKINESIS; OXYGEN CONSUMPTION; HIBERNATION THEORY;

D O I：

10.1097/00005344-199407000-00007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Regional myocardial O-2 consumption was measured in anesthetized dogs both in baseline conditions and during intracoronary infusion of lidocaine, verapamil, sodium citrate, or 2,3-butanedione-monoxime (BDM). Despite regional hypokinesis and dyskinesis during drug infusion, regional O-2 consumption was reduced only 30-40% by lidocaine, verapamil, and citrate and not at all by BDM. These results cast doubt on an important assumption of the ''hibernation'' theory: the protective matching of regional perfusion and contraction.

引用

页码：37 / 44

页数：8

共 31 条

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