RESPONSES TO PHENELZINE AND AMITRIPTYLINE ABSENCE OF DIFFERENTIAL PREDICTORS BY MULTIPLE-REGRESSION ANALYSIS

Multiple regression analyses using initial symptoms to predict outcome were carried out on data from a depressed outpatient controlled comparison of amitriptyline, phenelzine and placebo. Separate analyses were carried out in the 3 treatment groups and regression equations were compared. Significant prediction was obtained only for phenelzine. On only 1 of 3 outcome measures analyzed, however were there significant differences between treatment groups in regressions. Individual predictors were not easily interpretable. There was little evidence for different clinical predictors or response to phenelzine and amitriptyline in this sample.