SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF A SERIES OF AMINOPYRIDAZINE DERIVATIVES OF GAMMA-AMINOBUTYRIC-ACID ACTING AS SELECTIVE GABA-A ANTAGONISTS

被引：97

作者：

WERMUTH, CG ^{[1
]}

BOURGUIGNON, JJ ^{[1
]}

SCHLEWER, G ^{[1
]}

GIES, JP ^{[1
]}

SCHOENFELDER, A ^{[1
]}

MELIKIAN, A ^{[1
]}

BOUCHET, MJ ^{[1
]}

CHANTREUX, D ^{[1
]}

MOLIMARD, JC ^{[1
]}

HEAULME, M ^{[1
]}

CHAMBON, JP ^{[1
]}

BIZIERE, K ^{[1
]}

机构：

[1] GRP SANOFI,CTR RECH CLIN MIDY,F-34082 MONTPELLIER,FRANCE

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1987年 / 30卷 / 02期

关键词：

D O I：

10.1021/jm00385a003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：239 / 249

页数：11

共 67 条

[1] USE OF ALPHA-(ARYL)-4-MORPHOLINEACETONITRILES (MASKED ACYL ANION EQUIVALENTS) IN 1,4-ADDITIONS TO ALPHA,BETA-UNSATURATED ESTERS AND NITRILES - VERSATILE SYNTHETIC ROUTE TO 6-ARYL-3(2H)PYRIDAZINONES
ALBRIGHT, JD
MCEVOY, FJ
MORAN, DB
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1978, 15 (06) : 881 - 892
[2] SYNTHESIS AND ANXIOLYTIC ACTIVITY OF 6-(SUBSTITUTED-PHENYL)-1,2,4-TRIAZOLO[4,3-B]PYRIDAZINES
ALBRIGHT, JD
MORAN, DB
WRIGHT, WB
COLLINS, JB
BEER, B
LIPPA, AS
GREENBLATT, EN
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (05) : 592 - 600
[3] GABA AGONISTS AND ANTAGONISTS
ANDREWS, PR
JOHNSTON, GAR
[J]. BIOCHEMICAL PHARMACOLOGY, 1979, 28 (18) : 2697 - 2702
[4] ARIENS EJ, 1979, RECEPTORS COMPREHENS, V1, P33
[5] GABA AGONISTS AND POTENTIAL ANTAGONISTS RELATED TO MUSCIMOL
ARNT, J
KROGSGAARDLARSEN, P
[J]. BRAIN RESEARCH, 1979, 177 (02) : 395 - 400
[6] METHYLATION OF AMINOPYRIDAZINES
BARLIN, GB
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1976, (13): : 1424 - 1429
[7] SECURININE ALKALOIDS - A NEW CLASS OF GABA RECEPTOR ANTAGONIST
BEUTLER, JA
KARBON, EW
BRUBAKER, AN
MALIK, R
CURTIS, DR
ENNA, SJ
[J]. BRAIN RESEARCH, 1985, 330 (01) : 135 - 140
[8] CHARACTERIZATION OF SPECIFIC, HIGH-AFFINITY BINDING-SITES FOR GLUTAMIC-LABELED ACID IN RAT-BRAIN MEMBRANES
BIZIERE, K
THOMPSON, H
COYLE, JT
[J]. BRAIN RESEARCH, 1980, 183 (02) : 421 - 433
[9] BIZIERE K, 1982, ARZNEIMITTEL-FORSCH, V32-2, P824
[10] LACTONE CHEMISTRY - SYNTHESIS OF BETA-SUBSTITUTED, GAMMA-FUNCTIONALIZED BUTANOLIDES AND BUTENOLIDES AND SUCCINALDEHYDIC ACIDS FROM GLYOXYLIC-ACID
BOURGUIGNON, JJ
WERMUTH, CG
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1981, 46 (24) : 4889 - 4894

← 1 2 3 4 5 6 7 →