SYNTHESIS OF OPTICALLY-ACTIVE ALPHA,ALPHA-DISUBSTITUTED BETA-KETO-ESTERS VIA CHIRAL BETA-ENAMINO ESTERS

被引：42
作者：
GUINGANT, A
HAMMAMI, H
机构：
[1] Unité de Chimie Organique associée au CNRS, ESPCI, 75231 Paris Cedex 05
来源：
TETRAHEDRON-ASYMMETRY | 1991年 / 2卷 / 06期
关键词：
CHIRAL BETA-ENAMINO ESTERS; OPTICALLY ACTIVE BETA-KETO ESTERS; MICHAEL ADDITION; LEWIS ACID; HIGH PRESSURE;
D O I：
10.1016/S0957-4166(00)82164-3
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Michael addition of chiral beta-enamino esters to MVK and acrylates promoted by Lewis acids (ZnCl2, MgBr2) or high pressure (11-14 Kbar) afforded, after hydrolytic work-up, alpha,alpha-disubstituted beta-keto esters in good enantiomeric excesses.
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收藏
页码：411 / 414
页数：4
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