MALIGNANT MIXED MULLERIAN TUMOR VERSUS HIGH-GRADE ENDOMETRIAL CARCINOMA AND AGGRESSIVE VARIANTS OF ENDOMETRIAL CARCINOMA - A COMPARATIVE-ANALYSIS OF SURVIVAL

被引:77
作者
GEORGE, E
LILLEMOE, TJ
TWIGGS, LB
PERRONE, T
机构
[1] UNIV MINNESOTA, SCH MED, DEPT LAB MED & PATHOL, DIV SURG PATHOL, MINNEAPOLIS, MN 55455 USA
[2] UNIV MINNESOTA, SCH MED, CTR WOMENS CANC, MINNEAPOLIS, MN 55455 USA
[3] UNIV MINNESOTA, SCH MED, DEPT OBSTET & GYNECOL, MINNEAPOLIS, MN 55455 USA
关键词
CARCINOSARCOMA; CLEAR CELL CARCINOMA; ENDOMETRIAL CARCINOMA; ENDOMETRIAL NEOPLASMS; MALIGNANT MIXED MULLERIAN TUMORS; SEROUS CARCINOMA; UTERINE NEOPLASMS;
D O I
10.1097/00004347-199501000-00007
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
To ascertain whether uterine malignant mixed mullerian tumors are biologically distinct from high-grade endometrial carcinomas (FIGO grade 3), we compared patient survival in 32 and 39 cases, respectively. The Cox proportional hazard model was employed to determine whether tumor type was an independent predictor of survival. The survival of patients with MMMT was also compared to that of patients with serous adenocarcinoma and clear cell carcinoma. The 5-year overall and disease-free survival were significantly lower for malignant mixed mullerian tumors (25% and 11%) than for high-grade endometrial carcinomas (64% and 56%). Using the Cox proportional hazard model, tumor type (MMMT vs. high-grade endometrial carcinoma) was a statistically significant predictor of survival after other important prognostic variables such as pathologic stage, depth of myometrial invasion, and vascular invasion had been taken into account. The increased aggressiveness of MMMT appears most attributable to their tendency to reach a more advanced stage by the time of clinical presentation and to their greater propensity for upper abdominal dissemination. The survival of patients with MMMT was also lower than that of patients with the special histologic variants of endometrial carcinoma, serous adenocarcinoma and clear cell carcinoma, which are recognized for their unusually aggressive clinical behavior. These results indicate that uterine malignant mixed mullerian tumors are clinically more aggressive than high-grade endometrial carcinomas and should continue to be recognized as a distinct entity.
引用
收藏
页码:39 / 44
页数:6
相关论文
共 28 条
[1]   SEROUS PAPILLARY CARCINOMA OF THE ENDOMETRIUM - A HISTOPATHOLOGICAL STUDY OF 22 CASES [J].
ABELER, VM ;
KJORSTAD, KE .
GYNECOLOGIC ONCOLOGY, 1990, 39 (03) :266-271
[2]  
ABELER VM, 1991, CANCER, V67, P3093, DOI 10.1002/1097-0142(19910615)67:12<3093::AID-CNCR2820671226>3.0.CO
[3]  
2-L
[4]  
ABELER VM, 1991, CANCER, V68, P98, DOI 10.1002/1097-0142(19910701)68:1<98::AID-CNCR2820680120>3.0.CO
[5]  
2-R
[6]  
ABELER VM, 1991, GYNECOL ONCOL, V40, P207
[7]   THE SIGNIFICANCE OF EPITHELIAL DIFFERENTIATION IN MIXED MESODERMAL TUMORS OF THE UTERUS - A CLINICOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY [J].
BITTERMAN, P ;
CHUN, B ;
KURMAN, RJ .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1990, 14 (04) :317-328
[8]   ENDOMETRIAL PAPILLARY ADENOCARCINOMAS - 2 CLINICOPATHOLOGICAL TYPES [J].
CHEN, JL ;
TROST, DC ;
WILKINSON, EJ .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 1985, 4 (04) :279-288
[9]  
COX DR, 1972, J R STAT SOC B, V34, P187
[10]  
DEHNER LP, 1971, CANCER, V27, P207, DOI 10.1002/1097-0142(197101)27:1<207::AID-CNCR2820270129>3.0.CO