THE PHYSIOLOGICAL-ROLE OF NITRIC-OXIDE

被引:500
作者
BUTLER, AR [1 ]
WILLIAMS, DLH [1 ]
机构
[1] UNIV DURHAM,DEPT CHEM,DURHAM DH1 3LE,ENGLAND
关键词
D O I
10.1039/cs9932200233
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In the last six years it has become apparent that nitric oxide (NO) has a crucial and extensive role in human physiology. It acts as a messenger molecule effecting muscle relaxation, as a cytotoxic agent in the non-specific immune system, as a carcinogen, and as a neurotransmitter in the brain and peripheral nervous system. This article explores some of the chemistry of NO in an attempt to understand how such a modest molecule can play so many diverse roles.
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页码:233 / 241
页数:9
相关论文
共 55 条
[1]  
ARCHER S, 1993, FASEB J, V7, P350
[2]   AUTOXIDATION OF NO IN AQUEOUS-SOLUTION [J].
AWAD, HH ;
STANBURY, DM .
INTERNATIONAL JOURNAL OF CHEMICAL KINETICS, 1993, 25 (05) :375-381
[3]   APPARENT HYDROXYL RADICAL PRODUCTION BY PEROXYNITRITE - IMPLICATIONS FOR ENDOTHELIAL INJURY FROM NITRIC-OXIDE AND SUPEROXIDE [J].
BECKMAN, JS ;
BECKMAN, TW ;
CHEN, J ;
MARSHALL, PA ;
FREEMAN, BA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1620-1624
[4]   NITRIC-OXIDE MEDIATES GLUTAMATE-LINKED ENHANCEMENT OF CGMP LEVELS IN THE CEREBELLUM [J].
BREDT, DS ;
SNYDER, SH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (22) :9030-9033
[5]   ISOLATION OF NITRIC-OXIDE SYNTHETASE, A CALMODULIN-REQUIRING ENZYME [J].
BREDT, DS ;
SNYDER, SH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (02) :682-685
[6]   NITRIC-OXIDE AS AN INHIBITORY NONADRENERGIC NONCHOLINERGIC NEUROTRANSMITTER [J].
BULT, H ;
BOECKXSTAENS, GE ;
PELCKMANS, PA ;
JORDAENS, FH ;
VANMAERCKE, YM ;
HERMAN, AG .
NATURE, 1990, 345 (6273) :346-347
[7]   THE PENTACYANONITROSYLFERRATE ION .5. THE COURSE OF THE REACTIONS OF NITROPRUSSIDE WITH A RANGE OF THIOLS [J].
BUTLER, AR ;
CALSYHARRISON, AM ;
GLIDEWELL, C ;
SORENSEN, PE .
POLYHEDRON, 1988, 7 (13) :1197-1202
[8]   REACTIONS OF BIS-MU-IODO-BIS(DINITROSYLIRON) WITH HALIDE-IONS AND WITH THIOLS - AN ELECTRON-PARAMAGNETIC RESONANCE STUDY [J].
BUTLER, AR ;
GLIDEWELL, C ;
HYDE, AR ;
WALTON, JC .
POLYHEDRON, 1985, 4 (02) :303-306
[9]  
CHALLIS BC, 1979, J CHEM SOC P1, P229
[10]  
COOMBES RG, 1979, COMPREHENSIVE ORGANI, V2, P310