COULD CUB BE THE SITE OF REDOX LINKAGE IN CYTOCHROME-C-OXIDASE

被引：34

作者：

LARSEN, RW ^{[1
]}

PAN, LP ^{[1
]}

MUSSER, SM ^{[1
]}

LI, ZY ^{[1
]}

CHAN, SNI ^{[1
]}

机构：

[1] CALTECH, ARTHUR AMOS NOYES LAB CHEM PHYS, PASADENA, CA 91125 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 02期

关键词：

PROTON PUMP; ELECTRON TRANSFER; MITOCHONDRIA; RESPIRATION; OXYGEN REDUCTION;

D O I：

10.1073/pnas.89.2.723

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This paper explores the proton pumping function of cytochrome c oxidase [ferrocytochrome-c:oxygen oxidoreductase (EC 1.9.3.1)] based upon redox linkage at the "high-potential" CU(B) center. A model is proposed that is derived from a redox-linked ligand exchange mechanism previously described for the Cu(A) site. Qualitative analysis of this mechanism indicates that such a mechanism is feasible. However, the relatively short distance between Cu(B) and cytochrome a3 implies that the uncoupling electron transfers are quite facile. In addition, the position of the Cu(B) center with respect to the inner mitochondrial membrane argues against redox linkage at the Cu(B) site.

引用

页码：723 / 727

页数：5

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