MOLECULAR MODELING STUDIES AND THE CHROMATOGRAPHIC BEHAVIOR OF OXIRACETAM AND SOME CLOSELY RELATED MOLECULES

被引：13

作者：

CAMILLERI, P

MURPHY, JA

SAUNDERS, MR

THORPE, CJ

机构：

[1] Smith Kline Beecham Ltd., Welwyn, AL6 9AR, Herts, The Frythe

来源：

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN | 1991年 / 5卷 / 04期

关键词：

LACTAMS; CHIRAL CHROMATOGRAPHY; MOLECULAR MODELING;

D O I：

10.1007/BF00126662

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Modelling studies have been carried out on the cellulose-based chiral stationary phase used to separate the enantiomers of three simple lactams. These studies have helped in understanding differences in the chromatographic behaviour of these molecules.

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页码：277 / 284

页数：8

相关论文

共 7 条

[1] SPECIFICATION OF MOLECULAR CHIRALITY [J].

CAHN, RS ;

INGOLD, C ;

PRELOG, V .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1966, 5 (04) :385-&

[2] THE SPECIFICATION OF ASYMMETRIC CONFIGURATION IN ORGANIC CHEMISTRY [J].

CAHN, RS ;

INGOLD, CK ;

PRELOG, V .

EXPERIENTIA, 1956, 12 (03) :81-94

[3] DIRECT CHROMATOGRAPHIC-SEPARATION OF THE ENANTIOMERS OF OXIRACETAM [J].

CAMILLERI, P ;

MURPHY, JA ;

THORPE, C .

JOURNAL OF CHROMATOGRAPHY, 1990, 508 (01) :208-211

[4] CHROMATOGRAPHIC RESOLUTION .4. NOVEL PACKING MATERIAL FOR OPTICAL RESOLUTION - (+)-POLY(TRIPHENYLMETHYL METHACRYLATE) COATED ON MACROPOROUS SILICA-GEL [J].

OKAMOTO, Y ;

HONDA, S ;

OKAMOTO, I ;

YUKI, H ;

MURATA, S ;

NOYORI, R ;

TAKAYA, H .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (23) :6971-6973

[5] CHROMATOGRAPHIC OPTICAL RESOLUTION ON POLYSACCHARIDES AND THEIR DERIVATIVES [J].

SHIBATA, T ;

OKAMOTO, I ;

ISHII, K .

JOURNAL OF LIQUID CHROMATOGRAPHY, 1986, 9 (2-3) :313-340

[6] OXIRACETAM PREVENTS ELECTROSHOCK-INDUCED DECREASE IN BRAIN ACETYLCHOLINE AND AMNESIA [J].

SPIGNOLI, G ;

PEPEU, G .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 126 (03) :253-257

[7]

Vinter J G, 1987, J Comput Aided Mol Des, V1, P31, DOI 10.1007/BF01680556