BIOCHEMICAL EFFECTS OF TREATMENT WITH ORAL-CONTRACEPTIVE STEROIDS ON DOPAMINERGIC SYSTEM OF RAT

被引：28

作者：

ALGERI, S ^{[1
]}

PONZIO, F ^{[1
]}

DOLFINI, E ^{[1
]}

JORI, A ^{[1
]}

机构：

[1] IST RICERCHE FARMACOL MARIO NEGRI, I-20157 MILANO, ITALY

来源：

NEUROENDOCRINOLOGY | 1976年 / 22卷 / 04期

关键词：

D O I：

10.1159/000122643

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of acute and chronic administration of a combination of lynestrenol-mestranol, a widely employed contraceptive medication, on the dopaminergic system of the rat forebrain and striatum were investigated to better understand the biochemical basis of the neurological side-effects of steroid contraceptive drugs (SCD). Acute and chronic treatment increased the disappearance rate of striatal dopamine (DA) after synthesis blockade with .alpha.-methyl-p-tyrosine (.alpha.-MpT). Moreover, the conversion of 3H-tyrosine (3H-T) into 3H-DA was increased in the forebrain and striatum after chronic administration of this steroid combination. In the same animals, utilization of tyrosine (T) is increased.

引用

页码：343 / 351

页数：9

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