LIPOPHILIC DERIVATIVES OF CAFFEIC ACID AS LIPOXYGENASE INHIBITORS WITH ANTIOXIDANT PROPERTIES

被引:0
|
作者
MIRZOEVA, OK
SUDINA, GF
PUSHKAREVA, MA
KORSHUNOVA, GA
SUMBATYAN, NV
VARFOLOMEEV, SD
机构
来源
BIOORGANICHESKAYA KHIMIYA | 1995年 / 21卷 / 02期
关键词
CAFFEIC ACID; LIPOPHILIC DERIVATIVES; LIPOXYGENASE; ENZYME INHIBITION; RESPIRATORY BURST; XANTHINE OXIDASE;
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摘要
We have prepared two lipophilic derivatives of caffeic acid at the carboxylic function - caffeic acid phenethyl ester, an active component of propolis, and N,N'-dicyclohexyl-O-(3,4-dihydroxycinnamoyl)-isourea. Both substances inhibit barley 5-lipoxygenase and soybean 15-lipoxygenase at micromolar concentrations. The inhibition is uncompetitive;dose-dependent and reversible. The caffeic acid derivatives also exhibit antioxidant properties and at a concentration 5 - 10 mu M completely block the production of the reactive oxygen species in human neutrophils and in the cell-free xanthine/xanthine oxidase system.
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页码:143 / 151
页数:9
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