ENANTIOMERICALLY PURE EPOXYCHROMANS VIA ASYMMETRIC CATALYSIS

被引：170

作者：

LEE, NH ^{[1
]}

MUCI, AR ^{[1
]}

JACOBSEN, EN ^{[1
]}

机构：

[1] UNIV ILLINOIS,ROGER ADAMS LAB,DEPT CHEM,URBANA,IL 61801

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 38期

关键词：

D O I：

10.1016/S0040-4039(00)93426-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical and highly effective process for the asymmetric epoxidation of several 2,2-dimethylchromene derivatives is reported. Catalysis by Mn(salen) complex 4 in all cases affords epoxychromans with > 90% ee, and this method has been applied to the synthesis of two recently developed antihypertensive agents in enantiomerically pure form.

引用

页码：5055 / 5058

页数：4

共 16 条

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