THE BASIC SCIENCE OF GENE-THERAPY

被引：1502
作者：
MULLIGAN, RC [1 ]
机构：
[1] MIT, DEPT BIOL, CAMBRIDGE, MA 02142 USA
来源：
SCIENCE | 1993年 / 260卷 / 5110期
关键词：
D O I：
10.1126/science.8493530
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The development over the past decade of methods for delivering genes to mammalian cells has stimulated great interest in the possibility of treating human disease by gene-based therapies. However, despite substantial progress, a number of key technical issues need to be resolved before gene therapy can be safely and effectively applied in the clinic. Future technological developments, particularly in the areas of gene delivery and cell transplantion, will be critical for the successful practice of gene therapy.
引用
收藏
页码：926 / 932
页数：7
相关论文
共 108 条
[1]  
ANACHINI A, 1987, IMMUNOL TODAY, V8, P305
[2]   HUMAN GENE-THERAPY [J].
ANDERSON, WF .
SCIENCE, 1992, 256 (5058) :808-813
[3]   GENE-THERAPY - INTRACELLULAR IMMUNIZATION [J].
BALTIMORE, D .
NATURE, 1988, 335 (6189) :395-396
[4]   SYSTEMIC DELIVERY OF RECOMBINANT PROTEINS BY GENETICALLY MODIFIED MYOBLASTS [J].
BARR, E ;
LEIDEN, JM .
SCIENCE, 1991, 254 (5037) :1507-1509
[5]   A MAJORITY OF MICE SHOW LONG-TERM EXPRESSION OF A HUMAN BETA-GLOBIN GENE AFTER RETROVIRUS TRANSFER INTO HEMATOPOIETIC STEM-CELLS [J].
BENDER, MA ;
GELINAS, RE ;
MILLER, AD .
MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (04) :1426-1434
[6]  
BERKNER KL, 1988, BIOTECHNIQUES, V6, P616
[7]   COMBINATION OF INTERLEUKIN-3 AND INTERLEUKIN-6 PRESERVES STEM-CELL FUNCTION IN CULTURE AND ENHANCES RETROVIRUS-MEDIATED GENE-TRANSFER INTO HEMATOPOIETIC STEM-CELLS [J].
BODINE, DM ;
KARLSSON, S ;
NIENHUIS, AW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (22) :8897-8901
[8]  
BODINE DM, 1991, EXP HEMATOL, V19, P206
[9]   DEVELOPMENT OF A HIGH-TITER RETROVIRUS PRODUCER CELL-LINE CAPABLE OF GENE-TRANSFER INTO RHESUS-MONKEY HEMATOPOIETIC STEM-CELLS [J].
BODINE, DM ;
MCDONAGH, KT ;
BRANDT, SJ ;
NEY, PA ;
AGRICOLA, B ;
BYRNE, E ;
NIENHUIS, AW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (10) :3738-3742
[10]   TOWARD A GENETIC-ANALYSIS OF TUMOR REJECTION ANTIGENS [J].
BOON, T .
ADVANCES IN CANCER RESEARCH, 1992, 58 :177-210
12345678910