CONSTITUTIVE TRANSCRIPTION OF THE GENE FOR METALLOTHIONEIN IN A CADMIUM-RESISTANT YEAST

被引：0
|
作者：
TOHOYAMA, H
INAGAWA, A
KOIKE, H
INOUHE, M
JOHO, M
MURAYAMA, T
机构：
来源：
FEMS MICROBIOLOGY LETTERS | 1992年 / 95卷 / 01期
关键词：
YEAST; CADMIUM RESISTANCE; METALLOTHIONEIN; TRANSCRIPTION; GENE EXPRESSION; SACCHAROMYCES-CEREVISIAE;
D O I：
暂无
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A cadmium-resistant strain of Saccharomyces cerevisiae produces a cadmium metallothionein encoded by the CUP1 gene as does a copper-resistant strain. The mechanism of expression of the gene is inducible by copper ions in the copper-resistant strain. However, assays of CUP1-specific mRNA revealed that the transcription of the CUP1 gene in the cadmium-resistant strain is constitutive and the rate of transcription is further increased by exposure to cadmium or copper ions. This result was confirmed by the appearance of constitutive-expression segregants from diploid crosses between the cadmium-resistant strain and a strain with a reporter gene having the promoter of CUP1.
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页码：81 / 86
页数：6
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