METHODOLOGICAL CONSIDERATIONS IN MEASUREMENT OF THE P300 COMPONENT OF THE AUDITORY ODDBALL ERP IN SCHIZOPHRENIA

被引：26

作者：

GLABUS, MF

BLACKWOOD, DHR

EBMEIER, KP

SOUZA, V

WALKER, MT

SHARP, CW

DUNAN, JT

MUIR, W

机构：

[1] UNIV EDINBURGH,DEPT PSYCHIAT,EDINBURGH EH8 9YL,MIDLOTHIAN,SCOTLAND

[2] ROYAL EDINBURGH & ASSOCIATED HOSP,MRC,BRAIN METAB UNIT,EDINBURGH,MIDLOTHIAN,SCOTLAND

来源：

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY | 1994年 / 90卷 / 02期

关键词：

SCHIZOPHRENIA; EVENT-RELATED POTENTIALS; P300; HIGH-PASS FILTER; SPECTRAL ANALYSIS;

D O I：

10.1016/0013-4694(94)90004-3

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Twenty-three schizophrenic patients and 26 age-matched control subjects were studied using the P300 recorded during the auditory oddball task, with counting. Our aim was to assess the most suitable method of measurement and analysis of P300 amplitude and latency for use in clinical studies of schizophrenia. The effect of high-pass filtering, peak definition method and recording electrode site were all investigated. We have developed a technique, based on a least-mean-squares approximation to data, which seems particularly well suited to dealing with multi-peak P300 complexes. We have also investigated the spectral composition of the P300 and have found some evidence to support a proposed 2-frequency model of the P300 complex.

引用

页码：123 / 134

页数：12

共 21 条

[1] SCHIZOPHRENIA - A NEUROPHYSIOLOGICAL EVALUATION OF ABNORMAL INFORMATION-PROCESSING
BARIBEAUBRAUN, J
PICTON, TW
GOSSELIN, JY
[J]. SCIENCE, 1983, 219 (4586) : 874 - 876
[2] BRAIN INDICATORS OF ALTERED ATTENTION AND INFORMATION-PROCESSING IN SCHIZOPHRENIC-PATIENTS
BARRETT, K
MCCALLUM, WC
POCOCK, PV
[J]. BRITISH JOURNAL OF PSYCHIATRY, 1986, 148 : 414 - 420
[3] BLACKWOOD DHR, 1991, ARCH GEN PSYCHIAT, V48, P899
[4] BLACKWOOD DHR, 1987, BRIT J PSYCHIAT, V151, P506
[5] A COMPARISON OF METHODS FOR MEASURING EVENT-RELATED POTENTIALS
CALLAWAY, E
HALLIDAY, R
HERNING, RI
[J]. ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1983, 55 (02): : 227 - 232
[6] DENOTH F, 1986, CEREBRAL PSYCHOPHYSI, V38, P3
[7] A QUANTITATIVE METHOD FOR THE ASSESSMENT OF OVERALL EFFECTS FROM A NUMBER OF SIMILAR ELECTROPHYSIOLOGICAL STUDIES - DESCRIPTION AND APPLICATION TO EVENT-RELATED POTENTIALS IN PARKINSONS-DISEASE
EBMEIER, KP
[J]. ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1992, 84 (05): : 440 - 446
[8] LONG LATENCY EVENT-RELATED COMPONENTS OF THE AUDITORY EVOKED-POTENTIAL IN DEMENTIA
GOODIN, DS
SQUIRES, KC
STARR, A
[J]. BRAIN, 1978, 101 (DEC) : 635 - 648
[9] CLINICAL UTILITY OF LONG LATENCY COGNITIVE EVENT-RELATED POTENTIALS (P3) - THE PROS
GOODIN, DS
[J]. ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1990, 76 (01): : 2 - 5
[10] HARRIS FJ, 1978, P IEEE, V66, P51, DOI 10.1109/PROC.1978.10837

← 1 2 3 →