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CORRELATION BETWEEN LIPID-PEROXIDATION AND MORPHOLOGICAL MANIFESTATION OF PARAQUAT-INDUCED LUNG INJURY IN RATS
被引:48
作者
:
OGATA, T
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, 305, Tsukuba-city
OGATA, T
MANABE, S
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, 305, Tsukuba-city
MANABE, S
机构
:
[1]
Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, 305, Tsukuba-city
来源
:
ARCHIVES OF TOXICOLOGY
|
1990年
/ 64卷
/ 01期
关键词
:
Glutathione peroxidase;
Lipid peroxidation;
Lung injury;
Morphology;
Paraquat;
D O I
:
10.1007/BF01973370
中图分类号
:
R99 [毒物学(毒理学)];
学科分类号
:
100405 ;
摘要
:
Biochemical and morphological studies of rat lung were performed to determine the role of lipid peroxidation in the in vivo lung toxicity of paraquat. Two injections of 20 mg/kg paraquat were administered intraperitoneally every other day. While notable epithelial damage in the lungs was observed on the day after the second paraquat injection and progressed through the 5th day, the concentration of lipid peroxides in the rat lungs did not increase by the 3rd day after the injection. The lipid peroxide concentrations increased after the 5th day post-injection, and reached the maximum concentrations on the 7th day, when the damaged alveolar surface had been mostly repaired by regenerative pneumocytes. On the other hand, the delayed increase of lung lipid peroxides in paraquattreated rats paralleled the increased number of macrophages in the lung, which reached maximum numbers on the 7th day. Glutathione peroxidase activity in the lungs also increased with a similar time course. Macrophages from the lungs contained a large amount of engulfed degradation products and cellular debris, and immunohistochemical study showed high glutathione peroxidase content on the 5th and 7th days. These results suggest that lipid peroxidation is a relatively late event in the in vivo paraquat-treated lung and that the delayed increase of lipid peroxides in the lungs occurs from the phagocytic activities of macrophages rather than from toxic cell injury. © 1990 Springer-Verlag.
引用
收藏
页码:7 / 13
页数:7
相关论文
共 32 条
[1]
MECHANISM OF PARAQUAT TOXICITY IN MICE AND RATS
BUS, JS
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0
引用数:
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h-index:
0
机构:
MICHIGAN STATE UNIV, DEPT PHARMACOL, E LANSING, MI 48824 USA
MICHIGAN STATE UNIV, DEPT PHARMACOL, E LANSING, MI 48824 USA
BUS, JS
CAGEN, SZ
论文数:
0
引用数:
0
h-index:
0
机构:
MICHIGAN STATE UNIV, DEPT PHARMACOL, E LANSING, MI 48824 USA
MICHIGAN STATE UNIV, DEPT PHARMACOL, E LANSING, MI 48824 USA
CAGEN, SZ
OLGAARD, M
论文数:
0
引用数:
0
h-index:
0
机构:
MICHIGAN STATE UNIV, DEPT PHARMACOL, E LANSING, MI 48824 USA
MICHIGAN STATE UNIV, DEPT PHARMACOL, E LANSING, MI 48824 USA
OLGAARD, M
GIBSON, JE
论文数:
0
引用数:
0
h-index:
0
机构:
MICHIGAN STATE UNIV, DEPT PHARMACOL, E LANSING, MI 48824 USA
MICHIGAN STATE UNIV, DEPT PHARMACOL, E LANSING, MI 48824 USA
GIBSON, JE
[J].
TOXICOLOGY AND APPLIED PHARMACOLOGY,
1976,
35
(03)
: 501
-
513
[2]
BUS JS, 1975, RES COMMUN CHEM PATH, V11, P31
[3]
SUPEROXIDE-CATALYZED AND SINGLET OXYGEN-CATALYZED LIPID PEROXIDATION AS A POSSIBLE MECHANISM FOR PARAQUAT (METHYL VIOLOGEN) TOXICITY
BUS, JS
论文数:
0
引用数:
0
h-index:
0
机构:
MICHIGAN STATE UNIV, DEPT BIOCHEM, E LANSING, MI 48824 USA
BUS, JS
GIBSON, JE
论文数:
0
引用数:
0
h-index:
0
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MICHIGAN STATE UNIV, DEPT BIOCHEM, E LANSING, MI 48824 USA
GIBSON, JE
AUST, SD
论文数:
0
引用数:
0
h-index:
0
机构:
MICHIGAN STATE UNIV, DEPT BIOCHEM, E LANSING, MI 48824 USA
AUST, SD
[J].
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,
1974,
58
(03)
: 749
-
755
[4]
Bus JS, 1977, BIOCH MECHANISMS PAR, P157
[5]
BIPYRIDYLIUM QUATERNARY-SALTS AND RELATED COMPOUNDS .5. PULSE-RADIOLYSIS STUDIES OF REACTION OF PARAQUAT RADICAL WITH OXYGEN - IMPLICATIONS FOR MODE OF ACTION OF BIPYRIDYL HERBICIDES
FARRINGTON, JA
论文数:
0
引用数:
0
h-index:
0
机构:
IMPERIAL CHEM IND LTD, JEALOTTS HILL RES STN, BRACKNELL RG12 GEY, BERKSHIRE, ENGLAND
FARRINGTON, JA
EBERT, M
论文数:
0
引用数:
0
h-index:
0
机构:
IMPERIAL CHEM IND LTD, JEALOTTS HILL RES STN, BRACKNELL RG12 GEY, BERKSHIRE, ENGLAND
EBERT, M
LAND, EJ
论文数:
0
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0
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0
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IMPERIAL CHEM IND LTD, JEALOTTS HILL RES STN, BRACKNELL RG12 GEY, BERKSHIRE, ENGLAND
LAND, EJ
FLETCHER, K
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0
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0
h-index:
0
机构:
IMPERIAL CHEM IND LTD, JEALOTTS HILL RES STN, BRACKNELL RG12 GEY, BERKSHIRE, ENGLAND
FLETCHER, K
[J].
BIOCHIMICA ET BIOPHYSICA ACTA,
1973,
314
(03)
: 372
-
381
[6]
FUKUDA Y, 1985, AM J PATHOL, V118, P452
[7]
GEE JBL, 1976, J RETICULOENDOTH SOC, V19, P229
[8]
CATALASE-DEPENDENT PEROXIDATIVE METABOLISM IN ALVEOLAR MACROPHAGE DURING PHAGOCYTOSIS
GEE, JBL
论文数:
0
引用数:
0
h-index:
0
GEE, JBL
[J].
JOURNAL OF CLINICAL INVESTIGATION,
1970,
49
(06)
: 1280
-
&
[9]
CORRELATION OF BIOCHEMICAL AND MORPHOLOGIC MANIFESTATIONS OF ACUTE PULMONARY FIBROSIS IN RATS ADMINISTERED PARAQUAT
GREENBERG, DB
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF DAVIS,CALIF PRIMATE RES CTR,DEPT INTERNAL MED,PULM MED SECT,DAVIS,CA 95616
UNIV CALIF DAVIS,CALIF PRIMATE RES CTR,DEPT INTERNAL MED,PULM MED SECT,DAVIS,CA 95616
GREENBERG, DB
REISER, KM
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引用数:
0
h-index:
0
机构:
UNIV CALIF DAVIS,CALIF PRIMATE RES CTR,DEPT INTERNAL MED,PULM MED SECT,DAVIS,CA 95616
UNIV CALIF DAVIS,CALIF PRIMATE RES CTR,DEPT INTERNAL MED,PULM MED SECT,DAVIS,CA 95616
REISER, KM
LAST, JA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF DAVIS,CALIF PRIMATE RES CTR,DEPT INTERNAL MED,PULM MED SECT,DAVIS,CA 95616
UNIV CALIF DAVIS,CALIF PRIMATE RES CTR,DEPT INTERNAL MED,PULM MED SECT,DAVIS,CA 95616
LAST, JA
[J].
CHEST,
1978,
74
(04)
: 421
-
425
[10]
EPIGENETIC INTERCONVERSIONS OF MULTIPLE FORMS OF MOUSE LIVER CATALASE
HOLMES, RS
论文数:
0
引用数:
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h-index:
0
HOLMES, RS
MASTERS, CJ
论文数:
0
引用数:
0
h-index:
0
MASTERS, CJ
[J].
FEBS LETTERS,
1970,
11
(01)
: 45
-
&
←
1
2
3
4
→
共 32 条
[1]
MECHANISM OF PARAQUAT TOXICITY IN MICE AND RATS
BUS, JS
论文数:
0
引用数:
0
h-index:
0
机构:
MICHIGAN STATE UNIV, DEPT PHARMACOL, E LANSING, MI 48824 USA
MICHIGAN STATE UNIV, DEPT PHARMACOL, E LANSING, MI 48824 USA
BUS, JS
CAGEN, SZ
论文数:
0
引用数:
0
h-index:
0
机构:
MICHIGAN STATE UNIV, DEPT PHARMACOL, E LANSING, MI 48824 USA
MICHIGAN STATE UNIV, DEPT PHARMACOL, E LANSING, MI 48824 USA
CAGEN, SZ
OLGAARD, M
论文数:
0
引用数:
0
h-index:
0
机构:
MICHIGAN STATE UNIV, DEPT PHARMACOL, E LANSING, MI 48824 USA
MICHIGAN STATE UNIV, DEPT PHARMACOL, E LANSING, MI 48824 USA
OLGAARD, M
GIBSON, JE
论文数:
0
引用数:
0
h-index:
0
机构:
MICHIGAN STATE UNIV, DEPT PHARMACOL, E LANSING, MI 48824 USA
MICHIGAN STATE UNIV, DEPT PHARMACOL, E LANSING, MI 48824 USA
GIBSON, JE
[J].
TOXICOLOGY AND APPLIED PHARMACOLOGY,
1976,
35
(03)
: 501
-
513
[2]
BUS JS, 1975, RES COMMUN CHEM PATH, V11, P31
[3]
SUPEROXIDE-CATALYZED AND SINGLET OXYGEN-CATALYZED LIPID PEROXIDATION AS A POSSIBLE MECHANISM FOR PARAQUAT (METHYL VIOLOGEN) TOXICITY
BUS, JS
论文数:
0
引用数:
0
h-index:
0
机构:
MICHIGAN STATE UNIV, DEPT BIOCHEM, E LANSING, MI 48824 USA
BUS, JS
GIBSON, JE
论文数:
0
引用数:
0
h-index:
0
机构:
MICHIGAN STATE UNIV, DEPT BIOCHEM, E LANSING, MI 48824 USA
GIBSON, JE
AUST, SD
论文数:
0
引用数:
0
h-index:
0
机构:
MICHIGAN STATE UNIV, DEPT BIOCHEM, E LANSING, MI 48824 USA
AUST, SD
[J].
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,
1974,
58
(03)
: 749
-
755
[4]
Bus JS, 1977, BIOCH MECHANISMS PAR, P157
[5]
BIPYRIDYLIUM QUATERNARY-SALTS AND RELATED COMPOUNDS .5. PULSE-RADIOLYSIS STUDIES OF REACTION OF PARAQUAT RADICAL WITH OXYGEN - IMPLICATIONS FOR MODE OF ACTION OF BIPYRIDYL HERBICIDES
FARRINGTON, JA
论文数:
0
引用数:
0
h-index:
0
机构:
IMPERIAL CHEM IND LTD, JEALOTTS HILL RES STN, BRACKNELL RG12 GEY, BERKSHIRE, ENGLAND
FARRINGTON, JA
EBERT, M
论文数:
0
引用数:
0
h-index:
0
机构:
IMPERIAL CHEM IND LTD, JEALOTTS HILL RES STN, BRACKNELL RG12 GEY, BERKSHIRE, ENGLAND
EBERT, M
LAND, EJ
论文数:
0
引用数:
0
h-index:
0
机构:
IMPERIAL CHEM IND LTD, JEALOTTS HILL RES STN, BRACKNELL RG12 GEY, BERKSHIRE, ENGLAND
LAND, EJ
FLETCHER, K
论文数:
0
引用数:
0
h-index:
0
机构:
IMPERIAL CHEM IND LTD, JEALOTTS HILL RES STN, BRACKNELL RG12 GEY, BERKSHIRE, ENGLAND
FLETCHER, K
[J].
BIOCHIMICA ET BIOPHYSICA ACTA,
1973,
314
(03)
: 372
-
381
[6]
FUKUDA Y, 1985, AM J PATHOL, V118, P452
[7]
GEE JBL, 1976, J RETICULOENDOTH SOC, V19, P229
[8]
CATALASE-DEPENDENT PEROXIDATIVE METABOLISM IN ALVEOLAR MACROPHAGE DURING PHAGOCYTOSIS
GEE, JBL
论文数:
0
引用数:
0
h-index:
0
GEE, JBL
[J].
JOURNAL OF CLINICAL INVESTIGATION,
1970,
49
(06)
: 1280
-
&
[9]
CORRELATION OF BIOCHEMICAL AND MORPHOLOGIC MANIFESTATIONS OF ACUTE PULMONARY FIBROSIS IN RATS ADMINISTERED PARAQUAT
GREENBERG, DB
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF DAVIS,CALIF PRIMATE RES CTR,DEPT INTERNAL MED,PULM MED SECT,DAVIS,CA 95616
UNIV CALIF DAVIS,CALIF PRIMATE RES CTR,DEPT INTERNAL MED,PULM MED SECT,DAVIS,CA 95616
GREENBERG, DB
REISER, KM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF DAVIS,CALIF PRIMATE RES CTR,DEPT INTERNAL MED,PULM MED SECT,DAVIS,CA 95616
UNIV CALIF DAVIS,CALIF PRIMATE RES CTR,DEPT INTERNAL MED,PULM MED SECT,DAVIS,CA 95616
REISER, KM
LAST, JA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF DAVIS,CALIF PRIMATE RES CTR,DEPT INTERNAL MED,PULM MED SECT,DAVIS,CA 95616
UNIV CALIF DAVIS,CALIF PRIMATE RES CTR,DEPT INTERNAL MED,PULM MED SECT,DAVIS,CA 95616
LAST, JA
[J].
CHEST,
1978,
74
(04)
: 421
-
425
[10]
EPIGENETIC INTERCONVERSIONS OF MULTIPLE FORMS OF MOUSE LIVER CATALASE
HOLMES, RS
论文数:
0
引用数:
0
h-index:
0
HOLMES, RS
MASTERS, CJ
论文数:
0
引用数:
0
h-index:
0
MASTERS, CJ
[J].
FEBS LETTERS,
1970,
11
(01)
: 45
-
&
←
1
2
3
4
→