INHIBITION OF VISNA VIRUS-REPLICATION AND CYTOPATHIC EFFECT IN SHEEP CHOROID-PLEXUS CELL-CULTURES BY SELECTED ANTI-HIV AGENTS

被引：14

作者：

THORMAR, H ^{[1
]}

BALZARINI, J ^{[1
]}

DEBYSER, Z ^{[1
]}

WITVROUW, M ^{[1
]}

DESMYTER, J ^{[1
]}

DE CLERCQ, E ^{[1
]}

机构：

[1] KATHOLIEKE UNIV LEUVEN, REGA INST MED RES, B-3001 LOUVAIN, BELGIUM

来源：

ANTIVIRAL RESEARCH | 1995年 / 27卷 / 1-2期

关键词：

VISNA VIRUS; ANTIVIRAL AGENT; ANTI-HIV AGENT;

D O I：

10.1016/0166-3542(94)00082-J

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Several anti-HIV agents were tested against visna virus replication and cytopathic effect (CPE) in sheep choroid plexus cell cultures. Sulphated polysaccharides (i.e., dextran sulphate, pentosan polysulphate and heparin) and plant lectins, which inhibit viral adsorption and fusion, were found to be 10- to 40-fold less active against visna virus than against HIV. Bicyclam derivatives were at least 250-fold less active against visna virus and the highly HIV-1 specific TIBO derivatives were without a significant inhibitory effect on visna virus at subtoxic concentrations. In contrast, several 2',3'-dideoxynucleosides and acyclic nucleoside phosphonate analogues, which inhibit reverse transcription, were found to be very effective inhibitors of visna virus replication and viral CPE in cell culture.

引用

页码：49 / 57

页数：9

共 6 条

[1] ULTRASTRUCTURAL ASPECTS OF CELL-FUSION INDUCED BY VISNA VIRUS IN CELL-CULTURES OF SHEEP CHOROID-PLEXUS
PAUTRAT, G
BENKOEL, L
MICCO, PD
TAMALET, J
COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L ACADEMIE DES SCIENCES SERIE D, 1977, 285 (06): : 733 - &
[2] LONG-TERM VISNA VIRUS-INFECTION OF SHEEP CHOROID-PLEXUS CELLS - INITIATION AND PRELIMINARY CHARACTERIZATION OF CARRIER CULTURES
TROWBRIDGE, RS
INFECTION AND IMMUNITY, 1975, 11 (04) : 862 - 868
[3] ULTRASTRUCTURAL ASPECTS OF SHEEP CHOROID-PLEXUS CELLS IN CULTURE DURING EXOGENOUS CELL-FUSION INDUCED BY VISNA VIRUS
PAUTRAT, G
BENKOEL, L
DONADEY, C
COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L ACADEMIE DES SCIENCES SERIE D, 1980, 290 (12): : 771 - &
[4] CD8+ CELL ANTI-HIV ACTIVITY - NONLYTIC SUPPRESSION OF VIRUS-REPLICATION
MACKEWICZ, C
LEVY, JA
AIDS RESEARCH AND HUMAN RETROVIRUSES, 1992, 8 (06) : 1039 - 1050
[5] REPLICATION AND CYTOPATHIC EFFECT OF SOUTH GERMAN FIELD ISOLATES OF INFECTIOUS-BRONCHITIS VIRUS IN CELL-CULTURES AND THE EFFECT OF TRYPSIN
EMELE, J
LOHR, JE
KOSTERS, J
BERLINER UND MUNCHENER TIERARZTLICHE WOCHENSCHRIFT, 1985, 98 (06): : 216 - 219
[6] Inhibition of human immunodeficiency virus type 1 replication by nuclear chimeric anti-HIV ribozymes in a human T lymphoblastoid cell line
Michienzi, A
Conti, L
Varano, B
Prislei, S
Gessani, S
Bozzoni, I
HUMAN GENE THERAPY, 1998, 9 (05) : 621 - 628

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