EPITOPE DISCOVERY USING PEPTIDE LIBRARIES DISPLAYED ON PHAGE

被引：125
|
作者：
CORTESE, R
FELICI, F
GALFRE, G
LUZZAGO, A
MONACI, P
NICOSIA, A
机构：
[1] Istituto di Ricerche di Biologia Molecolare P. Angeletti, 00040 Pomezia, Roma
来源：
TRENDS IN BIOTECHNOLOGY | 1994年 / 12卷 / 07期
关键词：
D O I：
10.1016/0167-7799(94)90137-6
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Peptides displayed on phage, which mimic continuous and discontinuous epitopes, can be selected using purified antibodies or preparations of polyclonal serum. This review describes recent advances in this field, discusses the application of phage-display technology to the diagnosis of human diseases, and presents new ideas for the preparation of vaccines directed against specific epitopes on a pathogen.
引用
收藏
页码：262 / 267
页数：6
相关论文
共 50 条
  • [1] Epitope discovery using monoclonal antibodies and phage peptide libraries
    Yip, YL
    Ward, RL
    COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 1999, 2 (03) : 125 - 138
  • [2] BINDING EPITOPE OF SOMATOSTATIN DEFINED BY PHAGE-DISPLAYED PEPTIDE LIBRARIES
    WRIGHT, RM
    GRAM, H
    VATTAY, A
    BYRNE, S
    LAKE, P
    DOTTAVIO, D
    BIO-TECHNOLOGY, 1995, 13 (02): : 165 - 169
  • [3] Phage displayed peptide libraries
    Cesareni, G
    Castagnoli, L
    Cestra, G
    COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 1999, 2 (01) : 1 - 17
  • [4] Discovery of ligands for βγ subunits from phage-displayed peptide libraries
    Smrcka, AV
    Scott, JK
    G PROTEIN PATHWAYS PART B: G PROTEINS AND THEIR REGULATORS, 2002, 344 : 557 - 576
  • [5] Phage-displayed peptide libraries
    Zwick, MB
    Shen, JQ
    Scott, J
    CURRENT OPINION IN BIOTECHNOLOGY, 1998, 9 (04) : 427 - 436
  • [6] Epitope mapping of Mycoplasma hyopneumoniae using phage displayed peptide libraries and the immune responses of the selected phagotopes
    Yang, WJ
    Lai, JF
    Peng, KC
    Chiang, HJ
    Weng, JN
    Shiuan, D
    IMMUNOLOGY 2004: GENOMIC ISSUES, IMMUNE SYSTEM ACTIVATION AND ALLERGY, 2004, : 95 - 113
  • [7] Epitope mapping of Mycoplasma hyopneumoniae using phage displayed peptide libraries and the immune responses of the selected phagotopes
    Yang, WJ
    Lai, JF
    Peng, KC
    Chiang, HJ
    Weng, CN
    Shiuan, D
    JOURNAL OF IMMUNOLOGICAL METHODS, 2005, 304 (1-2) : 15 - 29
  • [8] Screening phage-displayed combinatorial peptide libraries
    Kay, BK
    Kasanov, J
    Yamabhai, M
    METHODS, 2001, 24 (03) : 240 - 246
  • [9] Epitope Mapping of Mono- and Polyclonal Antibodies by Screening Phage-displayed Random Peptide Libraries
    Molek, Peter
    Bratkovic, Tomaz
    ACTA CHIMICA SLOVENICA, 2016, 63 (04) : 914 - 919
  • [10] Requirement of multiple phage displayed peptide libraries for optimal mapping of a conformational antibody epitope on CCR5
    O'Connor, KH
    Königs, C
    Rowley, MJ
    Irving, JA
    Wijeyewickrema, LC
    Pustowka, A
    Dietrich, U
    Mackay, IR
    JOURNAL OF IMMUNOLOGICAL METHODS, 2005, 299 (1-2) : 21 - 35
12345