SEX-DEPENDENT LIVER METASTASIS OF HUMAN-MELANOMA LINES IN SCID MICE

被引：23

作者：

LADANYI, A

TIMAR, J

BOCSI, J

TOVARI, J

LAPIS, K

机构：

[1] 1st Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Budapest, H-1085

[2] National Institute of Health, National Cancer Institute, Bethesda, MD, 20892, 9000 Rockville Pike

来源：

MELANOMA RESEARCH | 1995年 / 5卷 / 02期

关键词：

MELANOMA; METASTASIS; SCID MICE; SEX HORMONES;

D O I：

10.1097/00008390-199504000-00002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The liver metastasis formation of two human melanoma cell lines were compared in male and female SCID mice. The intrasplenic injection of both tumour lines resulted in a significantly higher number of liver metastases in male than in female mice; the incidence and weight of spleen tumours, as well as the incidence of metastases were similar. Both melanoma cell lines bound fluorescent oestradiol, progesterone and testosterone conjugates, and proved to be positive for oestrogen receptor-related protein by immunocytochemistry, These observations support the view that endocrine factors influence the progression of human melanomas. This SCID mouse model could be useful in studying the effects of hormonal manipulations on human melanoma metastases.

引用

页码：83 / 86

页数：4

共 34 条

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