VASCULOTROPIN VASCULAR ENDOTHELIAL GROWTH-FACTOR INDUCES DIFFERENTIATION IN CULTURED OSTEOBLASTS

被引：250

作者：

MIDY, V ^{[1
]}

PLOUET, J ^{[1
]}

机构：

[1] LAB BIOL MOLEC EUCARYOTE,CNRS,UPR 9006,F-31062 TOULOUSE,FRANCE

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 199卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.1240

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vasculotropin/vascular endothelial growth factor (VAS/VEGF) is an angiogenic growth factor whose biological activity seems to be restricted in vitro to vascular endothelial cells. We describe here that fetal bovine osteoblasts (OB) bind VAS/VEGF but do not proliferate upon its addition. However VAS/VEGF induces migration, PTH-dependent cAMP accumulation and alkaline phosphatase increase when added to OB. The maximal effects reach levels comparable to that obtained with bone morphogenetic protein 2 (BMP-2), although the VAS/VEGF concentrations required are at least 100 fold lower. Our results suggest that VAS/VEGF could be an important regulator of osteoblastic differentiation. (C) 1994 Academic Press Inc.

引用

页码：380 / 386

页数：7

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