TITRATION PATTERNS OF A MURINE SARCOMA-LEUKEMIA VIRUS COMPLEX - EVIDENCE FOR EXISTENCE OF COMPETENT SARCOMA VIRIONS

被引：66

作者：

OCONNOR, TE

FISCHINGER, PJ

机构：

[1] Section of Molecular Virology, Leukemia and Lymphoma Branch, National Cancer Institute, Bethesda

来源：

SCIENCE | 1968年 / 159卷 / 3812期

关键词：

D O I：

10.1126/science.159.3812.325

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Stocks of murine sarcoma virus show titration patterns ranging from one- to two-hit kinetics. The comparison of various titrations of this virus, both with and without added helper virus, to theoretical model systems composed of defined constituents, suggests the existence of a sarcoma virus that does not need co-infecting murine leukemia virus to be manifested as a focus-forming unit. The behavior of such nondefective particles is compatible with a postulated leukemia-sarcoma virus hybrid.

引用

页码：325 / +

页数：1

共 12 条

[1]

CHIRIGOS MA, IN PRESS

[2]

DAMESHEK W, PERSPECTIVES LEUK ED

[3]

FISCHINGER PJ, IN PRESS

[4] PRODUCTION OF ALTERED CELL FOCI IN TISSUE CULTURE BY DEFECTIVE MOLONEY SARCOMA VIRUS PARTICLES [J].