mGluR5: a potential target for the treatment of Huntington's disease

被引：0
作者：
Ribeiro, Fabiola M. [1 ]
Doria, Juliana G. [1 ]
Ferguson, Stephen S. G. [2 ]
机构：
[1] Univ Fed Minas Gerais, ICB, Dept Bioquim & Imunol, Belo Horizonte, MG, Brazil
[2] Univ Western Ontario, J Allyn Taylor Ctr Cell Biol, London, ON, Canada
来源：
FUTURE NEUROLOGY | 2014年 / 9卷 / 03期
基金：
加拿大健康研究院;
关键词：
cell signaling; glutamate; Huntington's disease; mGluR5; neurodegeneration;
D O I：
10.2217/FNL.14.14
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
引用
收藏
页码：289 / 293
页数：5
相关论文
共 55 条
  • [41] Wild-type Huntingtin protects from apoptosis upstream of caspase-3
    Rigamonti, D
    Bauer, JH
    De-Fraja, C
    Conti, L
    Sipione, S
    Sciorati, C
    Clementi, E
    Hackam, A
    Hayden, MR
    Li, Y
    Cooper, JK
    Ross, CA
    Govoni, S
    Vincenz, C
    Cattaneo, E
    [J]. JOURNAL OF NEUROSCIENCE, 2000, 20 (10) : 3705 - 3713
  • [42] DISTRIBUTION OF METABOTROPIC GLUTAMATE-RECEPTOR MGLUR5 IMMUNOREACTIVITY IN RAT-BRAIN
    ROMANO, C
    SESMA, MA
    MCDONALD, CT
    OMALLEY, K
    VANDENPOL, AN
    OLNEY, JW
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1995, 355 (03) : 455 - 469
  • [43] PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis
    Rong, R
    Ahn, JY
    Huang, HL
    Nagata, E
    Kalman, D
    Kapp, JA
    Tu, JC
    Worley, PF
    Snyder, SH
    Ye, KQ
    [J]. NATURE NEUROSCIENCE, 2003, 6 (11) : 1153 - 1161
  • [44] The metabotropic glutamate receptor 5 antagonist MPEP and the mGluR2 agonist LY379268 modify disease progression in a transgenic mouse model of Huntington's disease
    Schlefer, J
    Sprünken, A
    Puls, C
    Luesse, HG
    Milkereit, A
    Milkereit, E
    Johann, V
    Kosinski, CM
    [J]. BRAIN RESEARCH, 2004, 1019 (1-2) : 246 - 254
  • [45] Positive and negative coupling of the metabotropic glutamate receptors to a G protein-activated K+ channel, GIRK, in Xenopus oocytes
    Sharon, D
    Vorobiov, D
    Dascal, N
    [J]. JOURNAL OF GENERAL PHYSIOLOGY, 1997, 109 (04) : 477 - 490
  • [46] Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus
    Shigemoto, R
    Kinoshita, A
    Wada, E
    Nomura, S
    Ohishi, H
    Takada, M
    Flor, PJ
    Neki, A
    Abe, T
    Nakanishi, S
    Mizuno, N
    [J]. JOURNAL OF NEUROSCIENCE, 1997, 17 (19) : 7503 - 7522
  • [47] IMMUNOHISTOCHEMICAL LOCALIZATION OF A METABOTROPIC GLUTAMATE-RECEPTOR, MGLUR5, IN THE RAT-BRAIN
    SHIGEMOTO, R
    NOMURA, S
    OHISHI, H
    SUGIHARA, H
    NAKANISHI, S
    MIZUNO, N
    [J]. NEUROSCIENCE LETTERS, 1993, 163 (01) : 53 - 57
  • [48] Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease
    Tang, TS
    Slow, E
    Lupu, V
    Stavrovskaya, IG
    Sugimori, M
    Llinás, R
    Kristal, BS
    Hayden, MR
    Bezprozvanny, I
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (07) : 2602 - 2607
  • [49] Huntingtin and Huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1
    Tang, TS
    Tu, HP
    Chan, EYW
    Maximov, A
    Wang, ZN
    Wellington, CL
    Hayden, MR
    Bezprozvanny, I
    [J]. NEURON, 2003, 39 (02) : 227 - 239
  • [50] Coupling of mGluR/Homer and PSD-95 complexes by the shank family of postsynaptic density proteins
    Tu, JC
    Xiao, B
    Naisbitt, S
    Yuan, JP
    Petralia, RS
    Brakeman, P
    Doan, A
    Aakalu, VK
    Lanahan, AA
    Sheng, M
    Worley, PF
    [J]. NEURON, 1999, 23 (03) : 583 - 592
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