ANXIOLYTIC EFFECT OF CCK-ANTAGONISTS ON PLUS-MAZE BEHAVIOR IN MICE

被引：73

作者：

RATAUD, J ^{[1
]}

DARCHE, F ^{[1
]}

PIOT, O ^{[1
]}

STUTZMANN, JM ^{[1
]}

BOHME, GA ^{[1
]}

BLANCHARD, JC ^{[1
]}

机构：

[1] RHONE POULENC SANTE,CTR RECH VITRY ALFORTVILLE,DEPT BIOL,13 QUAI JULES GUESDE,F-94403 VITRY,FRANCE

来源：

BRAIN RESEARCH | 1991年 / 548卷 / 1-2期

关键词：

ANXIETY; PLUS-MAZE TEST IN MICE; BEHAVIORAL STUDY; CHOLECYSTOKININ ANTAGONIST; CCK-A RECEPTOR; CCK-B RECEPTOR;

D O I：

10.1016/0006-8993(91)91139-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of systemic treatment with the CCK-B receptor antagonist L-365,260, its 3S-(-) enantiomer and the CCK-A receptor antagonist devazepide were assessed in the plus-maze procedure in mice. L-365,260 (1-1000-mu-g.kg-1 i.p.) produced a dose-dependent increase in the percentage of entries into, and the percentage of time spent in the open arms. Total arm entry was not consistently modified. Neither the 3S-(-) enantiomer of L-365,260 nor devazepide (both administered at 100-10.000-mu-g.kg-1) enhanced the exploratory behavior of mice. These results suggest that CCK-B, rather than CCK-A antagonists may possess 'anxiolytic' properties in mice.

引用

页码：315 / 317

页数：3

共 16 条

[1]

ABELSON JL, 1990, ARCH GEN PSYCHIAT, V47, P395

[2] BENZODIAZEPINE GASTRIN AND BRAIN CHOLECYSTOKININ RECEPTOR LIGANDS - L-365,260 [J].