MODULATORS OF MULTIDRUG-RESISTANCE - PRECLINICAL STUDIES

被引：92
作者：
FORD, JM
机构：
来源：
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 1995年 / 9卷 / 02期
关键词：
D O I：
10.1016/S0889-8588(18)30098-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Numerous compounds have been identified that sensitize multidrug-resistant cells to chemotherapeutic drugs in experimental systems. The mechanism of activity of these pharmacologic agents, termed chemosensitizers, appears to be mediated through direct inhibition of the drug efflux activity of the MDR1 gene product, P-glycoprotein. This article describes commonly used experimental models for the discovery and preclinical evaluation of new chemosensitizers, reviews those agents that possess potential for clinical use to circumvent multidrug resistance in humans, and discusses strategies to identify novel drugs of this type with improved efficacy and reduced toxicity.
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页码：337 / 361
页数：25
相关论文
共 132 条
[1]  
AFTAB DT, 1991, MOL PHARMACOL, V40, P798
[2]  
AISNER J, 1988, SEMIN ONCOL, V15, P68
[3]  
AKIYAMA SI, 1988, MOL PHARMACOL, V33, P144
[4]  
ALLEY MC, 1988, CANCER RES, V48, P589
[5]   PLASMA-CONCENTRATION - RESPONSE RELATIONSHIP OF VERAPAMIL IN THE TREATMENT OF ANGINA-PECTORIS [J].
ANDERSON, P ;
BONDESSON, U ;
SYLVEN, C ;
ASTROM, H .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1982, 4 (04) :609-614
[6]   THE GENE ENCODING MULTIDRUG RESISTANCE IS INDUCED AND EXPRESSED AT HIGH-LEVELS DURING PREGNANCY IN THE SECRETORY EPITHELIUM OF THE UTERUS [J].
ARCECI, RJ ;
CROOP, JM ;
HORWITZ, SB ;
HOUSMAN, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (12) :4350-4354
[7]  
BATIST G, 1986, J BIOL CHEM, V261, P5544
[8]   EFFECTS OF INDOLE ALKALOIDS ON MULTIDRUG RESISTANCE AND LABELING OF P-GLYCOPROTEIN BY A PHOTOAFFINITY ANALOG OF VINBLASTINE [J].
BECK, WT ;
CIRTAIN, MC ;
GLOVER, CJ ;
FELSTED, RL ;
SAFA, AR .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 153 (03) :959-966
[9]  
BIEDLER JL, 1970, CANCER RES, V30, P1174
[10]   RESTORATION OF DAUNOMYCIN RETENTION IN MULTIDRUG-RESISTANT P388 CELLS BY SUBMICROMOLAR CONCENTRATIONS OF SDZ PSC-833, A NONIMMUNOSUPPRESSIVE CYCLOSPORINE DERIVATIVE [J].
BOESCH, D ;
MULLER, K ;
POURTIERMANZANEDO, A ;
LOOR, F .
EXPERIMENTAL CELL RESEARCH, 1991, 196 (01) :26-32
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