COMPARATIVE-STUDY ON THE ANTITHROMBOTIC EFFICACY OF HIRUDIN, HEPARIN AND A LOW-MOLECULAR-WEIGHT HEPARIN IN PREVENTING EXPERIMENTALLY-INDUCED VENOUS THROMBOSIS

被引:0
作者
MONREAL, M [1 ]
GALEGO, G [1 ]
MONREAL, L [1 ]
ANGLES, AM [1 ]
MONASTERIO, J [1 ]
OLLER, B [1 ]
机构
[1] UNIV AUTONOMA BARCELONA,THROMBOSIS EXPTL UNIT,BARCELONA,SPAIN
关键词
PROPHYLAXIS; VENOUS THROMBOSIS; EXPERIMENTAL; HEPARIN; HIRUDIN; LOW-MOLECULAR-WEIGHT HEPARIN;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In a random, blind study, we compared the antithrombotic potential of unfractioned heparin, a low-molecular weight heparin (LMWH) and a recombinant hirudin (r-hirudin) given subcutaneously in a jugular vein thrombosis model in rabbits. All drugs and placebo were injected subcutaneously 2 h before inducing experimental thrombosis. A good thromboprophylactic effect was obtained with either LMWH and rhirudin as compared with placebo. By contrast, no significant differences were found between groups in bleeding time. We also found a small (non-significant) prolongation of the activated partial thromboplastin time in the r-hirudin-treated animals. As for thrombin time, r-hirudin-treated rabbits exhibited too much sensitivity, with noncoagulable end-points. In our study, r-hirudin at the dose used seemed to be as effective as LMWH is in the prophylaxis of venous thrombosis.
引用
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页码:179 / 183
页数:5
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