2 DISTINCT GENE SUBFAMILIES WITHIN THE FAMILY OF CYSTEINE PROTEASE GENES

被引:337
作者
KARRER, KM
PEIFFER, SL
DITOMAS, ME
机构
[1] Department of Biology, Marquette University, Milwaukee
[2] Department of Genetics, Washington University, St. Louis
关键词
TETRAHYMENA; PROPEPTIDE; CATHEPSIN;
D O I
10.1073/pnas.90.7.3063
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
A cDNA clone for a physiologically regulated Tetrahymena cysteine protease gene was sequenced. The nucleotide sequence predicts that the clone encodes a 336-amino acid protein composed of a 19-residue N-terminal signal sequence followed by a 107-residue propeptide and a 210-residue mature protein. Comparison of the deduced amino acid sequence of the protein with those of other cysteine proteases revealed a highly conserved interspersed amino acid motif in the propeptide region of the protein, the ERFNIN motif. The motif was present in all of the cysteine proteases in the data base with the exception of the cathepsin B-like proteins, which have shorter propeptides. Differences in the propeptides and in conserved amino acids of the mature proteins suggest that the ERFNIN proteases and the cathepsin B-like proteases constitute two distinct subfamilies within the cysteine proteases.
引用
收藏
页码:3063 / 3067
页数:5
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